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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Effects of endurance exercise training on inflammatory circulating progenitor cell content in lean and obese adults
|
|---|---|
| Published in |
Journal of Physiology, June 2018
|
| DOI | 10.1113/jp276023 |
| Pubmed ID | |
| Authors |
Grace M. Niemiro, Jacob M. Allen, Lucy J. Mailing, Naiman A. Khan, Hannah D. Holscher, Jeffrey A. Woods, Michael De Lisio |
| Abstract |
Chronic inflammation underlies many of the health decrements associated with obesity. Circulating progenitor cells can sense and respond to inflammatory stimuli, increasing the local inflammatory response within tissues. Here we show that 6 weeks of endurance exercise training significantly decreases inflammatory circulating progenitor cells in obese adults. These findings provide novel cellular mechanisms for the beneficial effects of exercise in obese adults. Circulating progenitor cells (CPCs) and subpopulations are normally found in the bone marrow, but can migrate to peripheral tissues to participate in local inflammation and/or remodelling. The purpose of this study was to compare the CPC response, particularly the inflammatory-primed haematopoietic stem and progenitor (HSPC) subpopulation, to a 6 week endurance exercise training (EET) intervention between lean and obese adults. Seventeen healthy weight (age: 23.9 ± 5.4 years, body mass index (BMI): 22.0 ± 2.6 kg m-2 ) and 10 obese (age: 29.0 ± 8.0 years, BMI: 33.1 ± 6.0 kg m-2 ) previously sedentary adults participated in an EET. Blood was collected before and after EET for quantification of CPCs and subpopulations via flow cytometry, colony forming unit assays and plasma concentrations of C-X-C motif chemokine 12 (CXCL12), granulocyte-colony stimulating factor (G-CSF), and chemokine (C-C motif) ligand 2 (CCL2). Exercise training reduced the number of circulating HSPCs and adipose tissue-derived mesenchymal stem cells (AT-MSCs). EET increased the colony forming potential of granulocytes and macrophages irrespective of BMI. EET reduced the number of HSPCs expressing the chemokine receptor CCR2 and the pro-inflammatory marker TLR4. EET-induced changes in adipose tissue-derived MSCs and bone marrow-derived MSCs were negatively related to changes in absolute fitness. Our results indicate that EET, regardless of BMI status, decreases CPCs and subpopulations, particularly those primed for contribution to tissue inflammation. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 33% |
| United Kingdom | 3 | 14% |
| Canada | 2 | 10% |
| Italy | 1 | 5% |
| Nigeria | 1 | 5% |
| Germany | 1 | 5% |
| Saudi Arabia | 1 | 5% |
| Unknown | 5 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 9 | 43% |
| Scientists | 6 | 29% |
| Practitioners (doctors, other healthcare professionals) | 4 | 19% |
| Science communicators (journalists, bloggers, editors) | 2 | 10% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 20% |
| Student > Bachelor | 7 | 11% |
| Student > Doctoral Student | 4 | 7% |
| Researcher | 4 | 7% |
| Student > Postgraduate | 3 | 5% |
| Other | 9 | 15% |
| Unknown | 22 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Sports and Recreations | 12 | 20% |
| Medicine and Dentistry | 6 | 10% |
| Nursing and Health Professions | 3 | 5% |
| Immunology and Microbiology | 3 | 5% |
| Agricultural and Biological Sciences | 2 | 3% |
| Other | 8 | 13% |
| Unknown | 27 | 44% |
Attention Score in Context
This research output has an Altmetric Attention Score of 127. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 May 2021.
All research outputs
#329,241
of 25,477,125 outputs
Outputs from Journal of Physiology
#186
of 9,789 outputs
Outputs of similar age
#7,168
of 341,824 outputs
Outputs of similar age from Journal of Physiology
#8
of 169 outputs
Altmetric has tracked 25,477,125 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 9,789 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 12.4. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 341,824 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 169 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.