| Title |
Transferrin receptors-targeting nanocarriers for efficient targeted delivery and transcytosis of drugs into the brain tumors: a review of recent advancements and emerging trends
|
|---|---|
| Published in |
Drug Delivery and Translational Research, June 2018
|
| DOI | 10.1007/s13346-018-0552-2 |
| Pubmed ID | |
| Authors |
Hira Choudhury, Manisha Pandey, Pei Xin Chin, Yee Lin Phang, Jeng Yuen Cheah, Shu Chien Ooi, Kit-Kay Mak, Mallikarjuna Rao Pichika, Prashant Kesharwani, Zahid Hussain, Bapi Gorain |
| Abstract |
Treatment of glioblastoma multiforme (GBM) is a predominant challenge in chemotherapy due to the existence of blood-brain barrier (BBB) which restricts delivery of chemotherapeutic agents to the brain together with the problem of drug penetration through hard parenchyma of the GBM. With the structural and mechanistic elucidation of the BBB under both physiological and pathological conditions, it is now viable to target central nervous system (CNS) disorders utilizing the presence of transferrin (Tf) receptors (TfRs). However, overexpression of these TfRs on the GBM cell surface can also help to avoid restrictions of GBM cells to deliver chemotherapeutic agents within the tumor. Therefore, targeting of TfR-mediated delivery could counteract drug delivery issues in GBM and create a delivery system that could cross the BBB effectively to utilize ligand-conjugated drug complexes through receptor-mediated transcytosis. Hence, approach towards successful delivery of antitumor agents to the gliomas has been making possible through targeting these overexpressed TfRs within the CNS and glioma cells. This review article presents a thorough analysis of current understanding on Tf-conjugated nanocarriers as efficient drug delivery system. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Portugal | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 132 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 132 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 14% |
| Student > Bachelor | 18 | 14% |
| Student > Master | 17 | 13% |
| Researcher | 13 | 10% |
| Student > Doctoral Student | 10 | 8% |
| Other | 20 | 15% |
| Unknown | 35 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Pharmacology, Toxicology and Pharmaceutical Science | 27 | 20% |
| Biochemistry, Genetics and Molecular Biology | 17 | 13% |
| Engineering | 7 | 5% |
| Chemistry | 6 | 5% |
| Agricultural and Biological Sciences | 5 | 4% |
| Other | 26 | 20% |
| Unknown | 44 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 June 2018.
All research outputs
#15,010,626
of 23,090,520 outputs
Outputs from Drug Delivery and Translational Research
#313
of 518 outputs
Outputs of similar age
#197,264
of 328,114 outputs
Outputs of similar age from Drug Delivery and Translational Research
#10
of 11 outputs
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So far Altmetric has tracked 518 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 36th percentile – i.e., 36% of its peers scored the same or lower than it.
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