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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antioxidants and free radical scavengers for the treatment of stroke, traumatic brain injury and aging.
|
|---|---|
| Published in |
Current Medicinal Chemistry, January 2008
|
| DOI | 10.2174/092986708783497337 |
| Pubmed ID | |
| Authors |
J E Slemmer, J J Shacka, M I Sweeney, J T Weber |
| Abstract |
The overproduction of reactive oxygen species (ROS) and reactive nitrogen species (RNS) is a common underlying mechanism of many neuropathologies, as they have been shown to damage various cellular components, including proteins, lipids and DNA. Free radicals, especially superoxide (O(2)*-), and non-radicals, such as hydrogen peroxide (H(2)O(2)), can be generated in quantities large enough to overwhelm endogenous protective enzyme systems, such as superoxide dismutase (SOD) and reduced glutathione (GSH). Here we review the mechanisms of ROS and RNS production, and their roles in ischemia, traumatic brain injury and aging. In particular, we discuss several acute and chronic pharmacological therapies that have been extensively studied in order to reduce ROS/RNS loads in cells and the subsequent oxidative stress, so-called "free-radical scavengers." Although the overall aim has been to counteract the detrimental effects of ROS/RNS in these pathologies, success has been limited, especially in human clinical studies. This review highlights some of the recent successes and failures in animal and human studies by attempting to link a compound's chemical structure with its efficacy as a free radical scavenger. In particular, we demonstrate how antioxidants derived from natural products, as well as long-term dietary alterations, may prove to be effective scavengers of ROS and RNS. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 104 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | <1% |
| China | 1 | <1% |
| Unknown | 102 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 20 | 19% |
| Researcher | 16 | 15% |
| Student > Master | 10 | 10% |
| Student > Bachelor | 8 | 8% |
| Professor > Associate Professor | 7 | 7% |
| Other | 17 | 16% |
| Unknown | 26 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 23 | 22% |
| Agricultural and Biological Sciences | 12 | 12% |
| Medicine and Dentistry | 9 | 9% |
| Chemistry | 8 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 6 | 6% |
| Other | 18 | 17% |
| Unknown | 28 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 15. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 October 2015.
All research outputs
#2,389,550
of 25,377,790 outputs
Outputs from Current Medicinal Chemistry
#123
of 3,099 outputs
Outputs of similar age
#8,668
of 168,393 outputs
Outputs of similar age from Current Medicinal Chemistry
#8
of 119 outputs
Altmetric has tracked 25,377,790 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 90th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,099 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 168,393 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 94% of its contemporaries.
We're also able to compare this research output to 119 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 93% of its contemporaries.