Title |
Blood‐Catalyzed RAFT Polymerization
|
---|---|
Published in |
Angewandte Chemie. International Edition, July 2018
|
DOI | 10.1002/anie.201802544 |
Pubmed ID | |
Authors |
Amin Reyhani, Mitchell D. Nothling, Hadi Ranji‐Burachaloo, Thomas G. McKenzie, Qiang Fu, Shereen Tan, Gary Bryant, Greg G. Qiao |
Abstract |
The use of hemoglobin (Hb) contained within red blood cells to drive a controlled radical polymerization via a reversible addition-fragmentation chain transfer (RAFT) process is reported for the first time. No pre-treatment of the Hb or cells was required prior to their use as polymerization catalysts, indicating the potential for synthetic engineering in complex biological microenvironments without the need for ex vivo techniques. Due to the naturally-occurring prevalence of the reagents employed in the catalytic system (Hb and hydrogen peroxide), this approach may facilitate the development of new strategies for in vivo cell engineering with synthetic macromolecules. |
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Saudi Arabia | 1 | 4% |
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United States | 1 | 4% |
Belgium | 1 | 4% |
Other | 3 | 12% |
Unknown | 4 | 16% |
Demographic breakdown
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Members of the public | 11 | 44% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 48 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 11 | 23% |
Student > Ph. D. Student | 11 | 23% |
Student > Bachelor | 7 | 15% |
Lecturer | 3 | 6% |
Student > Doctoral Student | 2 | 4% |
Other | 7 | 15% |
Unknown | 7 | 15% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 22 | 46% |
Biochemistry, Genetics and Molecular Biology | 5 | 10% |
Materials Science | 4 | 8% |
Engineering | 3 | 6% |
Unspecified | 2 | 4% |
Other | 3 | 6% |
Unknown | 9 | 19% |