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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A molecular mechanism for choosing alcohol over an alternative reward
|
|---|---|
| Published in |
Science, June 2018
|
| DOI | 10.1126/science.aao1157 |
| Pubmed ID | |
| Authors |
Eric Augier, Estelle Barbier, Russell S Dulman, Valentina Licheri, Gaëlle Augier, Esi Domi, Riccardo Barchiesi, Sean Farris, Daniel Nätt, R Dayne Mayfield, Louise Adermark, Markus Heilig |
| Abstract |
Alcohol addiction leads to increased choice of alcohol over healthy rewards. We established an exclusive choice procedure in which ~15% of outbred rats chose alcohol over a high-value reward. These animals displayed addiction-like traits, including high motivation to obtain alcohol and pursuit of this drug despite adverse consequences. Expression of the γ-aminobutyric acid (GABA) transporter GAT-3 was selectively decreased within the amygdala of alcohol-choosing rats, whereas a knockdown of this transcript reversed choice preference of rats that originally chose a sweet solution over alcohol. GAT-3 expression was selectively decreased in the central amygdala of alcohol-dependent people compared to those who died of unrelated causes. Impaired GABA clearance within the amygdala contributes to alcohol addiction, appears to translate between species, and may offer targets for new pharmacotherapies for treating this disorder. |
X Demographics
The data shown below were collected from the profiles of 726 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 130 | 18% |
| United States | 50 | 7% |
| United Kingdom | 11 | 2% |
| Sweden | 9 | 1% |
| Canada | 9 | 1% |
| France | 8 | 1% |
| Chile | 5 | <1% |
| Austria | 4 | <1% |
| China | 3 | <1% |
| Other | 29 | 4% |
| Unknown | 468 | 64% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 665 | 92% |
| Scientists | 48 | 7% |
| Science communicators (journalists, bloggers, editors) | 7 | <1% |
| Practitioners (doctors, other healthcare professionals) | 6 | <1% |
Mendeley readers
The data shown below were compiled from readership statistics for 363 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 363 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 57 | 16% |
| Researcher | 53 | 15% |
| Student > Bachelor | 45 | 12% |
| Student > Master | 40 | 11% |
| Student > Doctoral Student | 18 | 5% |
| Other | 60 | 17% |
| Unknown | 90 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 96 | 26% |
| Agricultural and Biological Sciences | 41 | 11% |
| Biochemistry, Genetics and Molecular Biology | 33 | 9% |
| Psychology | 28 | 8% |
| Medicine and Dentistry | 20 | 6% |
| Other | 40 | 11% |
| Unknown | 105 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 670. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 January 2023.
All research outputs
#32,242
of 25,722,279 outputs
Outputs from Science
#1,391
of 83,260 outputs
Outputs of similar age
#652
of 343,317 outputs
Outputs of similar age from Science
#53
of 1,173 outputs
Altmetric has tracked 25,722,279 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,260 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.9. This one has done particularly well, scoring higher than 98% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,317 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,173 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 95% of its contemporaries.