Title |
Adoptive immunotherapy for cancer: building on success
|
---|---|
Published in |
Nature Reviews Immunology, April 2006
|
DOI | 10.1038/nri1842 |
Pubmed ID | |
Authors |
Luca Gattinoni, Daniel J. Powell, Steven A. Rosenberg, Nicholas P. Restifo |
Abstract |
Adoptive cell transfer after host preconditioning by lymphodepletion represents an important advance in cancer immunotherapy. Here, we describe how a lymphopaenic environment enables tumour-reactive T cells to destroy large burdens of metastatic tumour and how the state of differentiation of the adoptively transferred T cells can affect the outcome of treatment. We also discuss how the translation of these new findings might further improve the efficacy of adoptive cell transfer through the use of vaccines, haematopoietic-stem-cell transplantation, modified preconditioning regimens, and alternative methods for the generation and selection of the T cells to be transferred. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 10 | 2% |
Germany | 4 | <1% |
Canada | 2 | <1% |
Italy | 1 | <1% |
Brazil | 1 | <1% |
Sweden | 1 | <1% |
Switzerland | 1 | <1% |
United Kingdom | 1 | <1% |
France | 1 | <1% |
Other | 2 | <1% |
Unknown | 554 | 96% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 130 | 22% |
Researcher | 117 | 20% |
Student > Master | 85 | 15% |
Student > Bachelor | 50 | 9% |
Professor > Associate Professor | 32 | 6% |
Other | 104 | 18% |
Unknown | 60 | 10% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 179 | 31% |
Medicine and Dentistry | 109 | 19% |
Biochemistry, Genetics and Molecular Biology | 74 | 13% |
Immunology and Microbiology | 74 | 13% |
Chemistry | 22 | 4% |
Other | 47 | 8% |
Unknown | 73 | 13% |