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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Generalised Anxiety Disorder – A Twin Study of Genetic Architecture, Genome-Wide Association and Differential Gene Expression
|
|---|---|
| Published in |
PLOS ONE, August 2015
|
| DOI | 10.1371/journal.pone.0134865 |
| Pubmed ID | |
| Authors |
Matthew N. Davies, Serena Verdi, Andrea Burri, Maciej Trzaskowski, Minyoung Lee, John M. Hettema, Rick Jansen, Dorret I. Boomsma, Tim D. Spector |
| Abstract |
Generalised Anxiety Disorder (GAD) is a common anxiety-related diagnosis, affecting approximately 5% of the adult population. One characteristic of GAD is a high degree of anxiety sensitivity (AS), a personality trait which describes the fear of arousal-related sensations. Here we present a genome-wide association study of AS using a cohort of 730 MZ and DZ female twins. The GWAS showed a significant association for a variant within the RBFOX1 gene. A heritability analysis of the same cohort also confirmed a significant genetic component with h2 of 0.42. Additionally, a subset of the cohort (25 MZ twins discordant for AS) was studied for evidence of differential expression using RNA-seq data. Significant differential expression of two exons with the ITM2B gene within the discordant MZ subset was observed, a finding that was replicated in an independent cohort. While previous research has shown that anxiety has a high comorbidity with a variety of psychiatric and neurodegenerative disorders, our analysis suggests a novel etiology specific to AS. |
X Demographics
The data shown below were collected from the profiles of 25 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 6 | 24% |
| United States | 4 | 16% |
| Sweden | 1 | 4% |
| Spain | 1 | 4% |
| Canada | 1 | 4% |
| Russia | 1 | 4% |
| Unknown | 11 | 44% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 18 | 72% |
| Scientists | 4 | 16% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
| Science communicators (journalists, bloggers, editors) | 1 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 123 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 123 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 28 | 23% |
| Researcher | 15 | 12% |
| Student > Master | 11 | 9% |
| Student > Doctoral Student | 9 | 7% |
| Student > Ph. D. Student | 9 | 7% |
| Other | 20 | 16% |
| Unknown | 31 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 25 | 20% |
| Agricultural and Biological Sciences | 14 | 11% |
| Medicine and Dentistry | 13 | 11% |
| Biochemistry, Genetics and Molecular Biology | 9 | 7% |
| Neuroscience | 8 | 7% |
| Other | 17 | 14% |
| Unknown | 37 | 30% |
Attention Score in Context
This research output has an Altmetric Attention Score of 30. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 July 2023.
All research outputs
#1,325,051
of 25,584,565 outputs
Outputs from PLOS ONE
#16,599
of 223,153 outputs
Outputs of similar age
#16,912
of 277,006 outputs
Outputs of similar age from PLOS ONE
#445
of 6,055 outputs
Altmetric has tracked 25,584,565 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 94th percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 223,153 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.8. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,006 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 93% of its contemporaries.
We're also able to compare this research output to 6,055 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.