| Title |
New Insights in Understanding and Treating Bone Fracture Pain
|
|---|---|
| Published in |
Current Osteoporosis Reports, June 2018
|
| DOI | 10.1007/s11914-018-0446-8 |
| Pubmed ID | |
| Authors |
Stefanie A. T. Mitchell, Lisa A. Majuta, Patrick W. Mantyh |
| Abstract |
This paper describes recent advances in understanding the mechanisms that drive fracture pain and how these findings are helping develop new therapies to treat fracture pain. Immediately following fracture, mechanosensitive nerve fibers that innervate bone are mechanically distorted. This results in these nerve fibers rapidly discharging and signaling the initial sharp fracture pain to the brain. Within minutes to hours, a host of neurotransmitters, cytokines, and nerve growth factor are released by cells at the fracture site. These factors stimulate, sensitize, and induce ectopic nerve sprouting of the sensory and sympathetic nerve fibers which drive the sharp pain upon movement and the dull aching pain at rest. If rapid and effective healing of the fracture occurs, these factors return to baseline and the pain subsides, but if not, these factors can drive chronic bone pain. New mechanism-based therapies have the potential to fundamentally change the way acute and chronic fracture pain is managed. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 7% |
| Italy | 1 | 7% |
| Qatar | 1 | 7% |
| Australia | 1 | 7% |
| Spain | 1 | 7% |
| Germany | 1 | 7% |
| Netherlands | 1 | 7% |
| Unknown | 8 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 14 | 93% |
| Scientists | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 127 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 13 | 10% |
| Student > Master | 10 | 8% |
| Researcher | 9 | 7% |
| Student > Ph. D. Student | 8 | 6% |
| Student > Postgraduate | 7 | 6% |
| Other | 18 | 14% |
| Unknown | 62 | 49% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 22 | 17% |
| Nursing and Health Professions | 11 | 9% |
| Neuroscience | 7 | 6% |
| Agricultural and Biological Sciences | 4 | 3% |
| Unspecified | 3 | 2% |
| Other | 14 | 11% |
| Unknown | 66 | 52% |
Attention Score in Context
This research output has an Altmetric Attention Score of 8. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2021.
All research outputs
#4,703,056
of 25,211,948 outputs
Outputs from Current Osteoporosis Reports
#94
of 608 outputs
Outputs of similar age
#83,695
of 335,632 outputs
Outputs of similar age from Current Osteoporosis Reports
#5
of 16 outputs
Altmetric has tracked 25,211,948 research outputs across all sources so far. Compared to these this one has done well and is in the 81st percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 608 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.4. This one has done well, scoring higher than 84% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 335,632 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 16 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.