| Title |
Recent Advances and Future of Gene Therapy for Bone Regeneration
|
|---|---|
| Published in |
Current Osteoporosis Reports, June 2018
|
| DOI | 10.1007/s11914-018-0459-3 |
| Pubmed ID | |
| Authors |
Galina Shapiro, Raphael Lieber, Dan Gazit, Gadi Pelled |
| Abstract |
The purpose of this review is to discuss the recent advances in gene therapy as a treatment for bone regeneration. While most fractures heal spontaneously, patients who present with fracture nonunion suffer from prolonged pain, disability, and often require additional operations to regain musculoskeletal function. In the last few years, BMP gene delivery by means of electroporation and sonoporation resulted in repair of nonunion bone defects in mice, rats, and minipigs. Ex vivo transfection of porcine mesenchymal stem cells (MSCs) resulted in bone regeneration following implantation in vertebral defects of minipigs. Sustained release of VEGF gene from a collagen-hydroxyapatite scaffold to the mandible of a human patient was shown to be safe and osteoinductive. In conclusion, gene therapy methods for bone regeneration are systematically becoming more efficient and show proof-of-concept in clinically relevant animal models. Yet, on the pathway to clinical use, more investigation is needed to determine the safety aspects of the various techniques in terms of biodistribution, toxicity, and tumorigenicity. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Netherlands | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Science communicators (journalists, bloggers, editors) | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 13 | 21% |
| Student > Ph. D. Student | 13 | 21% |
| Student > Bachelor | 4 | 7% |
| Researcher | 4 | 7% |
| Student > Doctoral Student | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 17 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 20% |
| Biochemistry, Genetics and Molecular Biology | 8 | 13% |
| Engineering | 7 | 11% |
| Agricultural and Biological Sciences | 3 | 5% |
| Chemical Engineering | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 21 | 34% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 July 2018.
All research outputs
#15,010,626
of 23,092,602 outputs
Outputs from Current Osteoporosis Reports
#300
of 550 outputs
Outputs of similar age
#181,968
of 301,979 outputs
Outputs of similar age from Current Osteoporosis Reports
#7
of 14 outputs
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