| Title |
Bone metastasis and the metastatic niche
|
|---|---|
| Published in |
Journal of Molecular Medicine, August 2015
|
| DOI | 10.1007/s00109-015-1329-4 |
| Pubmed ID | |
| Authors |
Guangwen Ren, Mark Esposito, Yibin Kang |
| Abstract |
The bone marrow has been long known to host a unique environment amenable to colonization by metastasizing tumor cells. Yet, the underlying molecular interactions within this specialized microenvironment which give rise to the high incidence of bone metastasis in breast and prostate cancer patients have long remained uncharacterized. With the recent description of the bone metastatic "niche," considerable focus has been placed on understanding how the bone stroma contributes to each step of metastasis. Discoveries within this field have demonstrated that when cancer cells home to the niche in which hematopoietic and mesenchymal stem/progenitor cells normally reside, a bidirectional crosstalk emerges between the tumor cells and the bone metastatic stroma. This communication modulates every step of cancer cell metastasis to the bone, including the initial homing and seeding, formation of micrometastases, outgrowth of macrometastases, and the maintenance of long-term dormancy of disseminated tumor cells in the bone. In clinical practice, targeting the bone metastatic niche is evolving into a promising avenue for the prevention of bone metastatic relapse, therapeutic resistance, and other aspects of cancer progression. Here, we review the current knowledge concerning the role of the bone metastatic niche in bone metastasis. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 153 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 24% |
| Student > Master | 24 | 16% |
| Researcher | 19 | 12% |
| Student > Bachelor | 13 | 8% |
| Student > Doctoral Student | 7 | 5% |
| Other | 13 | 8% |
| Unknown | 40 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 31 | 20% |
| Agricultural and Biological Sciences | 26 | 17% |
| Medicine and Dentistry | 25 | 16% |
| Engineering | 8 | 5% |
| Immunology and Microbiology | 5 | 3% |
| Other | 14 | 9% |
| Unknown | 44 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 February 2021.
All research outputs
#7,220,469
of 22,824,164 outputs
Outputs from Journal of Molecular Medicine
#474
of 1,551 outputs
Outputs of similar age
#84,982
of 263,348 outputs
Outputs of similar age from Journal of Molecular Medicine
#6
of 20 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. This one has received more attention than most of these and is in the 67th percentile.
So far Altmetric has tracked 1,551 research outputs from this source. They receive a mean Attention Score of 4.9. This one has gotten more attention than average, scoring higher than 67% of its peers.
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We're also able to compare this research output to 20 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.