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Use of Mesothelial Cells and Biological Matrices for Tissue Engineering of Simple Epithelium Surrogates

Overview of attention for article published in Frontiers in Bioengineering and Biotechnology, August 2015
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Title
Use of Mesothelial Cells and Biological Matrices for Tissue Engineering of Simple Epithelium Surrogates
Published in
Frontiers in Bioengineering and Biotechnology, August 2015
DOI 10.3389/fbioe.2015.00117
Pubmed ID
Authors

Christian Claude Lachaud, Berta Rodriguez-Campins, Abdelkrim Hmadcha, Bernat Soria

Abstract

Tissue-engineering technologies have progressed rapidly through last decades resulting in the manufacture of quite complex bioartificial tissues with potential use for human organ and tissue regeneration. The manufacture of avascular monolayered tissues such as simple squamous epithelia was initiated a few decades ago and is attracting increasing interest. Their relative morphostructural simplicity makes of their biomimetization a goal, which is currently accessible. The mesothelium is a simple squamous epithelium in nature and is the monolayered tissue lining the walls of large celomic cavities (peritoneal, pericardial, and pleural) and internal organs housed inside. Interestingly, mesothelial cells can be harvested in clinically relevant numbers from several anatomical sources and not less important, they also display high transdifferentiation capacities and are low immunogenic characteristics, which endow these cells with therapeutic interest. Their combination with a suitable scaffold (biocompatible, degradable, and non-immunogenic) may allow the manufacture of tailored serosal membranes biomimetics with potential spanning a wide range of therapeutic applications, principally for the regeneration of simple squamous-like epithelia such as the visceral and parietal mesothelium vascular endothelium and corneal endothelium among others. Herein, we review recent research progresses in mesothelial cells biology and their clinical sources. We make a particular emphasis on reviewing the different types of biological scaffolds suitable for the manufacture of serosal mesothelial membranes biomimetics. Finally, we also review progresses made in mesothelial cells-based therapeutic applications and propose some possible future directions.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 48 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 2%
Unknown 47 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 8 17%
Researcher 8 17%
Student > Master 7 15%
Student > Bachelor 5 10%
Student > Doctoral Student 3 6%
Other 9 19%
Unknown 8 17%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 13 27%
Agricultural and Biological Sciences 7 15%
Medicine and Dentistry 6 13%
Engineering 3 6%
Business, Management and Accounting 1 2%
Other 4 8%
Unknown 14 29%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 August 2015.
All research outputs
#18,423,683
of 22,824,164 outputs
Outputs from Frontiers in Bioengineering and Biotechnology
#3,396
of 6,549 outputs
Outputs of similar age
#191,848
of 266,077 outputs
Outputs of similar age from Frontiers in Bioengineering and Biotechnology
#32
of 49 outputs
Altmetric has tracked 22,824,164 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,549 research outputs from this source. They receive a mean Attention Score of 3.4. This one is in the 29th percentile – i.e., 29% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 266,077 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 16th percentile – i.e., 16% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.