You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
Mendeley readers
Attention Score in Context
| Title |
Phosphatidylinositol(4,5)bisphosphate coordinates actin-mediated mobilization and translocation of secretory vesicles to the plasma membrane of chromaffin cells
|
|---|---|
| Published in |
Nature Communications, October 2011
|
| DOI | 10.1038/ncomms1500 |
| Pubmed ID | |
| Authors |
Peter J. Wen, Shona L. Osborne, Mark Zanin, Pei Ching Low, Hai-Tao A. Wang, Simone M. Schoenwaelder, Shaun P. Jackson, Roland Wedlich-Söldner, Bart Vanhaesebroeck, Damien J. Keating, Frédéric A. Meunier |
| Abstract |
Neurosecretory vesicles undergo docking and priming before Ca(2+)-dependent fusion with the plasma membrane. Although de novo synthesis of phosphatidylinositol(4,5)bisphosphate (PtdIns(4,5)P(2)) is required for exocytosis, its precise contribution is still unclear. Here we show that inhibition of the p110δ isoform of PI3-kinase by IC87114 promotes a transient increase in PtdIns(4,5)P(2), leading to a potentiation of exocytosis in chromaffin cells. We then exploit this pathway to examine the effect of a transient PtdIns(4,5)P(2) increase on neurosecretory vesicles behaviour, outside the context of a secretagogue stimulation. Our results demonstrate that a rise in PtdIns(4,5)P(2) is sufficient to promote the mobilization and recruitment of secretory vesicles to the plasma membrane via Cdc42-mediated actin reorganization. PtdIns(4,5)P(2), therefore, orchestrates the actin-based conveyance of secretory vesicles to the plasma membrane. |
Mendeley readers
The data shown below were compiled from readership statistics for 46 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| India | 1 | 2% |
| United States | 1 | 2% |
| Australia | 1 | 2% |
| Unknown | 43 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 16 | 35% |
| Student > Ph. D. Student | 13 | 28% |
| Professor > Associate Professor | 3 | 7% |
| Student > Master | 3 | 7% |
| Student > Doctoral Student | 2 | 4% |
| Other | 4 | 9% |
| Unknown | 5 | 11% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 18 | 39% |
| Biochemistry, Genetics and Molecular Biology | 9 | 20% |
| Neuroscience | 5 | 11% |
| Medicine and Dentistry | 2 | 4% |
| Immunology and Microbiology | 1 | 2% |
| Other | 5 | 11% |
| Unknown | 6 | 13% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 October 2011.
All research outputs
#15,238,442
of 22,656,971 outputs
Outputs from Nature Communications
#41,569
of 46,540 outputs
Outputs of similar age
#91,940
of 132,884 outputs
Outputs of similar age from Nature Communications
#83
of 98 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 46,540 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.4. This one is in the 8th percentile – i.e., 8% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 132,884 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 18th percentile – i.e., 18% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 98 others from the same source and published within six weeks on either side of this one. This one is in the 9th percentile – i.e., 9% of its contemporaries scored the same or lower than it.