Title |
In-hospital contact investigation among health care workers after exposure to smear-negative tuberculosis
|
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Published in |
Journal of Occupational Medicine and Toxicology, June 2009
|
DOI | 10.1186/1745-6673-4-11 |
Pubmed ID | |
Authors |
Felix C Ringshausen, Stephan Schlösser, Albert Nienhaus, Anja Schablon, Gerhard Schultze-Werninghaus, Gernot Rohde |
Abstract |
Smear-negative pulmonary tuberculosis (TB) accounts for a considerable proportion of TB transmission, which especially endangers health care workers (HCW). Novel Mycobacterium-tuberculosis-specific interferon-gamma release assays (IGRAs) may offer the chance to define the burden of TB in HCW more accurately than the Mantoux tuberculin skin test (TST), but the data that is available regarding their performance in tracing smear-negative TB in the low-incidence, in-hospital setting, is limited. We conducted a large-scale, in-hospital contact investigation among HCW of a German university hospital after exposure to a single case of extensive smear-negative, culture-positive TB with pulmonary involvement. The objective of the present study was to evaluate an IGRA in comparison to the TST and to identify risk factors for test positivity. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | 3% |
Iran, Islamic Republic of | 1 | 1% |
South Africa | 1 | 1% |
Unknown | 63 | 94% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Researcher | 18 | 27% |
Student > Master | 12 | 18% |
Other | 4 | 6% |
Student > Ph. D. Student | 4 | 6% |
Professor | 4 | 6% |
Other | 17 | 25% |
Unknown | 8 | 12% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 35 | 52% |
Agricultural and Biological Sciences | 5 | 7% |
Immunology and Microbiology | 4 | 6% |
Biochemistry, Genetics and Molecular Biology | 3 | 4% |
Nursing and Health Professions | 2 | 3% |
Other | 6 | 9% |
Unknown | 12 | 18% |