| Title |
Immunoparalysis and nosocomial infection in children with multiple organ dysfunction syndrome
|
|---|---|
| Published in |
Intensive Care Medicine, December 2010
|
| DOI | 10.1007/s00134-010-2088-x |
| Pubmed ID | |
| Authors |
Mark W. Hall, Nina L. Knatz, Carol Vetterly, Steven Tomarello, Mark D. Wewers, Hans Dieter Volk, Joseph A. Carcillo |
| Abstract |
Immunoparalysis defined by prolonged monocyte human leukocyte antigen DR depression is associated with adverse outcomes in adult severe sepsis and can be reversed with granulocyte macrophage colony-stimulating factor (GM-CSF). We hypothesized that immunoparalysis defined by whole-blood ex vivo lipopolysaccharide-induced tumor necrosis factor-alpha (TNFα) response <200 pg/mL beyond day 3 of multiple organ dysfunction syndrome (MODS) is similarly associated with nosocomial infection in children and can be reversed with GM-CSF. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 155 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Indonesia | 1 | <1% |
| Mexico | 1 | <1% |
| United States | 1 | <1% |
| Unknown | 152 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 25 | 16% |
| Student > Master | 22 | 14% |
| Student > Ph. D. Student | 17 | 11% |
| Student > Doctoral Student | 14 | 9% |
| Student > Bachelor | 12 | 8% |
| Other | 31 | 20% |
| Unknown | 34 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 65 | 42% |
| Immunology and Microbiology | 9 | 6% |
| Psychology | 9 | 6% |
| Agricultural and Biological Sciences | 7 | 5% |
| Biochemistry, Genetics and Molecular Biology | 7 | 5% |
| Other | 19 | 12% |
| Unknown | 39 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 94. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2020.
All research outputs
#374,903
of 22,656,971 outputs
Outputs from Intensive Care Medicine
#324
of 4,967 outputs
Outputs of similar age
#1,527
of 180,337 outputs
Outputs of similar age from Intensive Care Medicine
#1
of 25 outputs
Altmetric has tracked 22,656,971 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,967 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 26.5. This one has done particularly well, scoring higher than 93% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 180,337 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 25 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.