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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Role of osteopontin in decidualization and pregnancy success
|
|---|---|
| Published in |
Reproduction, February 2018
|
| DOI | 10.1530/rep-17-0782 |
| Pubmed ID | |
| Authors |
Xiao-Bo Wang, Qian-Rong Qi, Kai-Lin Wu, Qing-Zhen Xie |
| Abstract |
OPN is essential for blastocyst implantation and placentation. Previous study found that miR181a was increased while miR181b was down-regulated in endometrium during decidualization. However, the information regarding their effects on decidualization in human endometrium is still limited. Here we report a novel role of OPN and miR181b in uterine decidualization and pregnancy success in humans. The expression of OPN was high in endometrium in secretory phase and in vitro decidualized hESC, whereas miR181b expression was low in identical conditions. Further analysis confirmed that OPN expression was up-regulated by cAMP and C/EBPβ signal pathway, while down-regulated by miR181b. Increased OPN expression could promote the expression of decidualization-related and angiogenesis-related genes. Conversely, the processes of decidualization and angiogenesis in hESC were compromised by inhibiting OPN expression in vitro. OPN expression was repressed in implantation failure group when compared with successful pregnancy group in IVF/ICSI-ET cycles. These findings add a new line of evidence supporting the fact that OPN is involved in decidualization and pregnancy success. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 33% |
| Bulgaria | 1 | 33% |
| Unknown | 1 | 33% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Science communicators (journalists, bloggers, editors) | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 23 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 23 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 4 | 17% |
| Student > Bachelor | 2 | 9% |
| Other | 2 | 9% |
| Researcher | 2 | 9% |
| Student > Master | 2 | 9% |
| Other | 3 | 13% |
| Unknown | 8 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 7 | 30% |
| Biochemistry, Genetics and Molecular Biology | 3 | 13% |
| Agricultural and Biological Sciences | 2 | 9% |
| Arts and Humanities | 1 | 4% |
| Veterinary Science and Veterinary Medicine | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 9 | 39% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2018.
All research outputs
#14,418,409
of 23,092,602 outputs
Outputs from Reproduction
#1,974
of 2,734 outputs
Outputs of similar age
#240,308
of 439,676 outputs
Outputs of similar age from Reproduction
#24
of 33 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,734 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one is in the 25th percentile – i.e., 25% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 439,676 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 33 others from the same source and published within six weeks on either side of this one. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.