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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Interleukin-21-Producing CD4+ T Cells Promote Type 2 Immunity to House Dust Mites
|
|---|---|
| Published in |
Immunity, August 2015
|
| DOI | 10.1016/j.immuni.2015.07.015 |
| Pubmed ID | |
| Authors |
Jonathan M. Coquet, Martijn J. Schuijs, Mark J. Smyth, Kim Deswarte, Rudi Beyaert, Harald Braun, Louis Boon, Gunilla B. Karlsson Hedestam, Steven L. Nutt, Hamida Hammad, Bart N. Lambrecht |
| Abstract |
Asthma is a T helper 2 (Th2)-cell-mediated disease; however, recent findings implicate Th17 and innate lymphoid cells also in regulating airway inflammation. Herein, we have demonstrated profound interleukin-21 (IL-21) production after house dust mite (HDM)-driven asthma by using T cell receptor (TCR) transgenic mice reactive to Dermatophagoides pteronyssinus 1 and an IL-21GFP reporter mouse. IL-21-producing cells in the mediastinal lymph node (mLN) bore characteristics of T follicular helper (Tfh) cells, whereas IL-21(+) cells in the lung did not express CXCR5 (a chemokine receptor expressed by Tfh cells) and were distinct from effector Th2 or Th17 cells. Il21r(-/-) mice developed reduced type 2 responses and the IL-21 receptor (IL-21R) enhanced Th2 cell function in a cell-intrinsic manner. Finally, administration of recombinant IL-21 and IL-25 synergistically promoted airway eosinophilia primarily via effects on CD4(+) lymphocytes. This highlights an important Th2-cell-amplifying function of IL-21-producing CD4(+) T cells in allergic airway inflammation. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 13% |
| United Kingdom | 2 | 13% |
| Sweden | 1 | 6% |
| South Africa | 1 | 6% |
| Belgium | 1 | 6% |
| Italy | 1 | 6% |
| Unknown | 8 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 44% |
| Scientists | 6 | 38% |
| Practitioners (doctors, other healthcare professionals) | 2 | 13% |
| Science communicators (journalists, bloggers, editors) | 1 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 153 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | <1% |
| Sweden | 1 | <1% |
| France | 1 | <1% |
| Unknown | 150 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 33 | 22% |
| Researcher | 27 | 18% |
| Student > Master | 18 | 12% |
| Student > Bachelor | 15 | 10% |
| Professor | 10 | 7% |
| Other | 25 | 16% |
| Unknown | 25 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Immunology and Microbiology | 46 | 30% |
| Agricultural and Biological Sciences | 32 | 21% |
| Medicine and Dentistry | 22 | 14% |
| Biochemistry, Genetics and Molecular Biology | 19 | 12% |
| Unspecified | 3 | 2% |
| Other | 6 | 4% |
| Unknown | 25 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 November 2015.
All research outputs
#4,207,698
of 25,374,917 outputs
Outputs from Immunity
#2,426
of 4,816 outputs
Outputs of similar age
#49,802
of 276,431 outputs
Outputs of similar age from Immunity
#35
of 62 outputs
Altmetric has tracked 25,374,917 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,816 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 276,431 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 62 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.