Title |
The intestinal microbiome in human disease and how it relates to arthritis and spondyloarthritis
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Published in |
Best Practice & Research Clinical Rheumatology, August 2015
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DOI | 10.1016/j.berh.2015.08.001 |
Pubmed ID | |
Authors |
Mary-Ellen Costello, Philip C. Robinson, Helen Benham, Matthew A. Brown |
Abstract |
Humans and microbes have developed a symbiotic relationship over time, and alterations in this symbiotic relationship have been linked to several immune mediated diseases such as inflammatory bowel disease, type 1 diabetes and spondyloarthropathies. Improvements in sequencing technologies, coupled with a renaissance in 16S rRNA gene based community profiling, have enabled the characterization of microbiomes throughout the body including the gut. Improved characterization and understanding of the human gut microbiome means the gut flora is progressively being explored as a target for novel therapies including probiotics and faecal microbiota transplants. These innovative therapies are increasingly used for patients with debilitating conditions where conventional treatments have failed. This review discusses the current understanding of the interplay between host genetics and the gut microbiome in the pathogenesis of spondyloarthropathies, and how this may relate to potential therapies for these conditions. |
X Demographics
Geographical breakdown
Country | Count | As % |
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United States | 3 | 20% |
United Kingdom | 3 | 20% |
Canada | 1 | 7% |
Australia | 1 | 7% |
Italy | 1 | 7% |
Unknown | 6 | 40% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 14 | 93% |
Scientists | 1 | 7% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | 1% |
Unknown | 97 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 16 | 16% |
Researcher | 14 | 14% |
Other | 11 | 11% |
Student > Postgraduate | 8 | 8% |
Student > Bachelor | 8 | 8% |
Other | 20 | 20% |
Unknown | 21 | 21% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 41 | 42% |
Agricultural and Biological Sciences | 13 | 13% |
Biochemistry, Genetics and Molecular Biology | 7 | 7% |
Immunology and Microbiology | 4 | 4% |
Nursing and Health Professions | 3 | 3% |
Other | 7 | 7% |
Unknown | 23 | 23% |