| Title |
The role of epidermal sphingolipids in dermatologic diseases
|
|---|---|
| Published in |
Lipids in Health and Disease, January 2016
|
| DOI | 10.1186/s12944-016-0178-7 |
| Pubmed ID | |
| Authors |
Sonia Borodzicz, Lidia Rudnicka, Dagmara Mirowska-Guzel, Agnieszka Cudnoch-Jedrzejewska |
| Abstract |
Sphingolipids, a group of lipids containing the sphingoid base, have both structural and biological functions in human epidermis. Ceramides, as a part of extracellular lipids in the stratum corneum, are important elements of the skin barrier and are involved in the prevention of transepidermal water loss. In addition, ceramides regulate such processes as proliferation, differentiation and apoptosis of keratinocytes. Another important sphingolipid, sphingosine-1-phosphate (S1P), inhibits proliferation and induces differentiation of keratinocytes. A recent clinical study of the efficacy and safety of ponesimod (a selective modulator of the S1P receptor 1) suggested that sphingolipid metabolism may become a new target for the pharmacological treatment of psoriasis. The role of sphingolipids in some dermatologic diseases, including psoriasis, atopic dermatitis and ichthyoses was summarized in this article. |
Mendeley readers
The data shown below were compiled from readership statistics for 106 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 106 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 19 | 18% |
| Student > Master | 16 | 15% |
| Researcher | 13 | 12% |
| Student > Doctoral Student | 6 | 6% |
| Student > Postgraduate | 6 | 6% |
| Other | 17 | 16% |
| Unknown | 29 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 17 | 16% |
| Medicine and Dentistry | 15 | 14% |
| Agricultural and Biological Sciences | 7 | 7% |
| Chemistry | 7 | 7% |
| Pharmacology, Toxicology and Pharmaceutical Science | 7 | 7% |
| Other | 18 | 17% |
| Unknown | 35 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 35. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2022.
All research outputs
#995,366
of 23,318,744 outputs
Outputs from Lipids in Health and Disease
#74
of 1,475 outputs
Outputs of similar age
#19,223
of 396,884 outputs
Outputs of similar age from Lipids in Health and Disease
#2
of 27 outputs
Altmetric has tracked 23,318,744 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 95th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,475 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 396,884 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 27 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 92% of its contemporaries.