| Title |
Intrauterine Inflammation, Epigenetics, and Microbiome Influences on Preterm Infant Health
|
|---|---|
| Published in |
Current Pathobiology Reports, January 2018
|
| DOI | 10.1007/s40139-018-0159-9 |
| Pubmed ID | |
| Authors |
Lei Lu, Erika C. Claud |
| Abstract |
Significant research reveals that the microbiome modulates perinatal and postnatal health. This review aims to examine mechanisms by which intrauterine infection, the epigenome, and microbiome specifically influence preterm infant health outcomes. Intrauterine infection is a primary cause of preterm birth and can cause alterations in gene expression and epigenetic programming as well as postnatal inflammatory responses in the offspring. Insights from our own studies demonstrate epigenetic modifications of TLRs associated with exposure to intrauterine inflammation, as well as a cross talk between host epigenome and microbiome. Lastly, the gut microbiome modulates maturation of inflammatory pathways, which influences the development of preterm infants. We present a unifying theme that preterm infant outcomes are associated with modulation of host immune and inflammatory responses, which are influenced by acute intrauterine infection, epigenetic, and microbiome factors. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 3 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 3 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 56 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 56 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 16% |
| Student > Bachelor | 8 | 14% |
| Student > Postgraduate | 4 | 7% |
| Student > Doctoral Student | 4 | 7% |
| Researcher | 3 | 5% |
| Other | 8 | 14% |
| Unknown | 20 | 36% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 8 | 14% |
| Medicine and Dentistry | 8 | 14% |
| Nursing and Health Professions | 7 | 13% |
| Biochemistry, Genetics and Molecular Biology | 5 | 9% |
| Immunology and Microbiology | 3 | 5% |
| Other | 4 | 7% |
| Unknown | 21 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 June 2018.
All research outputs
#3,661,446
of 23,092,602 outputs
Outputs from Current Pathobiology Reports
#13
of 104 outputs
Outputs of similar age
#81,297
of 441,524 outputs
Outputs of similar age from Current Pathobiology Reports
#3
of 6 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 104 research outputs from this source. They receive a mean Attention Score of 3.7. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 3 of them.