Title |
Transcriptional regulation of Annexin A2 promotes starvation-induced autophagy
|
---|---|
Published in |
Nature Communications, August 2015
|
DOI | 10.1038/ncomms9045 |
Pubmed ID | |
Authors |
Kevin Moreau, Ghita Ghislat, Warren Hochfeld, Maurizio Renna, Eszter Zavodszky, Gautam Runwal, Claudia Puri, Shirley Lee, Farah Siddiqi, Fiona M. Menzies, Brinda Ravikumar, David C. Rubinsztein |
Abstract |
Autophagy is an important degradation pathway, which is induced after starvation, where it buffers nutrient deprivation by recycling macromolecules in organisms from yeast to man. While the classical pathway mediating this response is via mTOR inhibition, there are likely to be additional pathways that support the process. Here, we identify Annexin A2 as an autophagy modulator that regulates autophagosome formation by enabling appropriate ATG9A trafficking from endosomes to autophagosomes via actin. This process is dependent on the Annexin A2 effectors ARP2 and Spire1. Annexin A2 expression increases after starvation in cells in an mTOR-independent fashion. This is mediated via Jun N-terminal kinase activation of c-Jun, which, in turn, enhances the trans-activation of the Annexin A2 promoter. Annexin A2 knockdown abrogates starvation-induced autophagy, while its overexpression induces autophagy. Hence, c-Jun-mediated transcriptional responses support starvation-induced autophagy by regulating Annexin A2 expression levels. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
Unknown | 3 | 75% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Practitioners (doctors, other healthcare professionals) | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 84 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 18 | 21% |
Researcher | 15 | 18% |
Student > Ph. D. Student | 15 | 18% |
Student > Bachelor | 8 | 10% |
Student > Postgraduate | 4 | 5% |
Other | 10 | 12% |
Unknown | 14 | 17% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 31 | 37% |
Agricultural and Biological Sciences | 16 | 19% |
Medicine and Dentistry | 10 | 12% |
Neuroscience | 7 | 8% |
Computer Science | 2 | 2% |
Other | 2 | 2% |
Unknown | 16 | 19% |