| Title |
Health-related outcomes of critically ill patients with and without sepsis
|
|---|---|
| Published in |
Intensive Care Medicine, June 2018
|
| DOI | 10.1007/s00134-018-5274-x |
| Pubmed ID | |
| Authors |
Kelly Thompson, Colman Taylor, Stephen Jan, Qiang Li, Naomi Hammond, John Myburgh, Manoj Saxena, Balasubramanian Venkatesh, Simon Finfer |
| Abstract |
To determine differences in health-related quality of life (HRQoL), survival and healthcare resource use of critically ill adults with and without sepsis. We conducted a primary propensity score matched analysis of patients with and without sepsis enrolled in a large multicentre clinical trial. Outcomes included HRQoL at 6 months, survival to 2 years, length of ICU and hospital admission and cost of ICU and hospital treatment to 2 years. We obtained linked data for 3442 (97.3%) of 3537 eligible patients and matched 806/905 (89.0%) patients with sepsis with 806/2537 (31.7%) without. After matching, there were no significant differences in the proportion of survivors with and without sepsis reporting problems with mobility (37.8% vs. 38.7%, p = 0.86), self-care (24.7% vs. 26.0%, p = 0.44), usual activities (44.5% vs. 46.8%, p = 0.28), pain/discomfort (42.4% vs. 41.6%, p = 0.54) and anxiety/depression (36.9% vs. 37.7%, p = 0.68). There was no significant difference in survival at 2 years: 482/792 (60.9%) vs. 485/799 (60.7%) (HR 1.01, 95% CI 0.86-1.18, p = 0.94). The initial ICU and hospital admission were longer for patients with sepsis: 10.1 ± 11.9 vs. 8.0 ± 9.8 days (p < 0.0001) and 22.8 ± 21.2 vs. 19.1 ± 19.0 days, (p = 0.0003) respectively. The cost of ICU admissions was higher for patients with sepsis: A$43,345 ± 46,263 (€35,109 ± 35,043) versus 34,844 ± 38,281 (€28,223 ± 31,007), mean difference $8501 (€6885), 95% CI $4342-12,660 (€3517 ± 10,254), p < 0.001 as was the total cost of hospital treatment to 2 years: A$74,120 ± 60,750 (€60,037 ± 49,207) versus A$65,806 ± 59,856 (€53,302 ± 48,483), p = 0.005. Critically ill patients with sepsis have higher healthcare resource use and costs but similar survival and HRQoL compared to matched patients without sepsis. |
X Demographics
The data shown below were collected from the profiles of 75 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Australia | 16 | 21% |
| United States | 11 | 15% |
| United Kingdom | 9 | 12% |
| France | 3 | 4% |
| Argentina | 2 | 3% |
| Netherlands | 2 | 3% |
| India | 2 | 3% |
| Mexico | 2 | 3% |
| Canada | 2 | 3% |
| Other | 4 | 5% |
| Unknown | 22 | 29% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 48 | 64% |
| Scientists | 15 | 20% |
| Practitioners (doctors, other healthcare professionals) | 10 | 13% |
| Science communicators (journalists, bloggers, editors) | 2 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 72 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 72 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 11 | 15% |
| Other | 8 | 11% |
| Researcher | 7 | 10% |
| Student > Ph. D. Student | 6 | 8% |
| Student > Bachelor | 5 | 7% |
| Other | 15 | 21% |
| Unknown | 20 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 19 | 26% |
| Nursing and Health Professions | 16 | 22% |
| Social Sciences | 3 | 4% |
| Business, Management and Accounting | 2 | 3% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Other | 4 | 6% |
| Unknown | 26 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 41. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 December 2020.
All research outputs
#995,091
of 25,382,250 outputs
Outputs from Intensive Care Medicine
#941
of 5,395 outputs
Outputs of similar age
#21,294
of 336,265 outputs
Outputs of similar age from Intensive Care Medicine
#30
of 131 outputs
Altmetric has tracked 25,382,250 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 96th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 5,395 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 29.7. This one has done well, scoring higher than 82% of its peers.
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We're also able to compare this research output to 131 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.