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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Meta-analysis of modifiable risk factors for Alzheimer's disease
|
|---|---|
| Published in |
Journal of neurology, neurosurgery and psychiatry, August 2015
|
| DOI | 10.1136/jnnp-2015-310548 |
| Pubmed ID | |
| Authors |
Wei Xu, Lan Tan, Hui-Fu Wang, Teng Jiang, Meng-Shan Tan, Lin Tan, Qing-Fei Zhao, Jie-Qiong Li, Jun Wang, Jin-Tai Yu |
| Abstract |
The aetiology of Alzheimer's disease (AD) is believed to involve environmental exposure and genetic susceptibility. The aim of our present systematic review and meta-analysis was to roundly evaluate the association between AD and its modifiable risk factors. We systematically searched PubMed and the Cochrane Database of Systematic Reviews from inception to July 2014, and the references of retrieved relevant articles. We included prospective cohort studies and retrospective case-control studies. 16 906 articles were identified of which 323 with 93 factors met the inclusion criteria for meta-analysis. Among factors with relatively strong evidence (pooled population >5000) in our meta-analysis, we found grade I evidence for 4 medical exposures (oestrogen, statin, antihypertensive medications and non-steroidal anti-inflammatory drugs therapy) as well as 4 dietary exposures (folate, vitamin E/C and coffee) as protective factors of AD. We found grade I evidence showing that one biochemical exposure (hyperhomocysteine) and one psychological condition (depression) significantly increase risk of developing AD. We also found grade I evidence indicative of complex roles of pre-existing disease (frailty, carotid atherosclerosis, hypertension, low diastolic blood pressure, type 2 diabetes mellitus (Asian population) increasing risk whereas history of arthritis, heart disease, metabolic syndrome and cancer decreasing risk) and lifestyle (low education, high body mass index (BMI) in mid-life and low BMI increasing the risk whereas cognitive activity, current smoking (Western population), light-to-moderate drinking, stress, high BMI in late-life decreasing the risk) in influencing AD risk. We identified no evidence suggestive of significant association with occupational exposures. Effective interventions in diet, medications, biochemical exposures, psychological condition, pre-existing disease and lifestyle may decrease new incidence of AD. |
X Demographics
The data shown below were collected from the profiles of 268 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 37 | 14% |
| United States | 34 | 13% |
| Spain | 22 | 8% |
| Canada | 16 | 6% |
| Australia | 11 | 4% |
| Japan | 4 | 1% |
| Argentina | 3 | 1% |
| Ireland | 3 | 1% |
| France | 3 | 1% |
| Other | 27 | 10% |
| Unknown | 108 | 40% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 184 | 69% |
| Practitioners (doctors, other healthcare professionals) | 39 | 15% |
| Scientists | 38 | 14% |
| Science communicators (journalists, bloggers, editors) | 7 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 968 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | <1% |
| Germany | 2 | <1% |
| Greece | 2 | <1% |
| Italy | 1 | <1% |
| Brazil | 1 | <1% |
| Canada | 1 | <1% |
| Colombia | 1 | <1% |
| Sweden | 1 | <1% |
| Japan | 1 | <1% |
| Other | 0 | 0% |
| Unknown | 953 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 145 | 15% |
| Student > Bachelor | 126 | 13% |
| Researcher | 114 | 12% |
| Student > Ph. D. Student | 107 | 11% |
| Student > Doctoral Student | 54 | 6% |
| Other | 173 | 18% |
| Unknown | 249 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 222 | 23% |
| Psychology | 82 | 8% |
| Neuroscience | 78 | 8% |
| Nursing and Health Professions | 55 | 6% |
| Biochemistry, Genetics and Molecular Biology | 52 | 5% |
| Other | 180 | 19% |
| Unknown | 299 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 501. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 February 2023.
All research outputs
#52,326
of 25,654,806 outputs
Outputs from Journal of neurology, neurosurgery and psychiatry
#22
of 7,432 outputs
Outputs of similar age
#463
of 278,050 outputs
Outputs of similar age from Journal of neurology, neurosurgery and psychiatry
#1
of 63 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 7,432 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 14.2. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,050 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.