| Title |
Executive dysfunctions differentially predict amotivation in first-episode schizophrenia-spectrum disorder: a prospective 1-year follow-up study
|
|---|---|
| Published in |
European Archives of Psychiatry and Clinical Neuroscience, June 2018
|
| DOI | 10.1007/s00406-018-0918-y |
| Pubmed ID | |
| Authors |
Wing Chung Chang, Jasmine Tsz Ting Liu, Christy Lai Ming Hui, Sherry Kit Wa Chan, Edwin Ho Ming Lee, Yi Nam Suen, Eric Yu Hai Chen |
| Abstract |
Amotivation is a major determinant of functional outcome in schizophrenia but it is understudied in the early course of illness. There is a paucity of longitudinal research investigating predictors of amotivation. In this study, we aimed to examine baseline cognitive and clinical predictors of amotivation at 6 and 12 months of follow-up in patients aged 18-55 years presenting with first-episode DSM-IV schizophrenia-spectrum disorder (FES). Of 145 patients recruited at intake, 116 and 113 completed assessments at 6- and 12-month follow-up, respectively. Amotivation was measured by avolition-apathy and anhedonia-asociality subscale scores of the Scale of the Assessment of Negative Symptoms. Cognitive assessment was administered at baseline. As executive dysfunction has been more consistently found to be associated with negative symptoms and amotivation in prior literature, we adopted fractionated approach to subdivide executive function into distinct components encompassing switching and flexibility, response initiation, response inhibition, planning and strategy allocation, sustained attention and working memory. Our results showed that baseline amotivation (p = 0.01) and switching and flexibility (p = 0.01) were found to independently predict amotivation at 6 months follow-up. Baseline amotivation (p < 0.01) and switching and flexibility (albeit with trend-wise significance, p = 0.06) were also retained in final multivariate regression model for 12-month amotivation prediction. No other executive components or cognitive domains predicted amotivation at follow-up. Findings of our study thus indicate amotivation at initial presentation as a critical determinant of subsequent motivational deficits over 1 year of treatment for FES patients. Cognitive flexibility might be specifically related to the development of amotivation in the early stage of illness. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Practitioners (doctors, other healthcare professionals) | 1 | 50% |
| Members of the public | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 59 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 59 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 24% |
| Student > Ph. D. Student | 8 | 14% |
| Researcher | 5 | 8% |
| Student > Postgraduate | 4 | 7% |
| Professor | 3 | 5% |
| Other | 7 | 12% |
| Unknown | 18 | 31% |
| Readers by discipline | Count | As % |
|---|---|---|
| Psychology | 15 | 25% |
| Medicine and Dentistry | 6 | 10% |
| Business, Management and Accounting | 3 | 5% |
| Neuroscience | 3 | 5% |
| Nursing and Health Professions | 2 | 3% |
| Other | 3 | 5% |
| Unknown | 27 | 46% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2018.
All research outputs
#18,550,468
of 23,815,455 outputs
Outputs from European Archives of Psychiatry and Clinical Neuroscience
#939
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Outputs of similar age
#239,788
of 330,088 outputs
Outputs of similar age from European Archives of Psychiatry and Clinical Neuroscience
#13
of 18 outputs
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