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Mendeley readers
Attention Score in Context
| Title |
Two‐Photon‐Excited Silica and Organosilica Nanoparticles for Spatiotemporal Cancer Treatment
|
|---|---|
| Published in |
Advanced Healthcare Materials, January 2018
|
| DOI | 10.1002/adhm.201701248 |
| Pubmed ID | |
| Authors |
Jonas G. Croissant, Jeffrey I. Zink, Laurence Raehm, Jean‐Olivier Durand |
| Abstract |
Coherent two-photon-excited (TPE) therapy in the near-infrared (NIR) provides safer cancer treatments than current therapies lacking spatial and temporal selectivities because it is characterized by a 3D spatial resolution of 1 µm3 and very low scattering. In this review, the principle of TPE and its significance in combination with organosilica nanoparticles (NPs) are introduced and then studies involving the design of pioneering TPE-NIR organosilica nanomaterials are discussed for bioimaging, drug delivery, and photodynamic therapy. Organosilica nanoparticles and their rich and well-established chemistry, tunable composition, porosity, size, and morphology provide ideal platforms for minimal side-effect therapies via TPE-NIR. Mesoporous silica and organosilica nanoparticles endowed with high surface areas can be functionalized to carry hydrophobic and biologically unstable two-photon absorbers for drug delivery and diagnosis. Currently, most light-actuated clinical therapeutic applications with NPs involve photodynamic therapy by singlet oxygen generation, but low photosensitizing efficiencies, tumor resistance, and lack of spatial resolution limit their applicability. On the contrary, higher photosensitizing yields, versatile therapies, and a unique spatial resolution are available with engineered two-photon-sensitive organosilica particles that selectively impact tumors while healthy tissues remain untouched. Patients suffering pathologies such as retinoblastoma, breast, and skin cancers will greatly benefit from TPE-NIR ultrasensitive diagnosis and therapy. |
Mendeley readers
The data shown below were compiled from readership statistics for 80 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 80 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 16% |
| Student > Master | 9 | 11% |
| Student > Bachelor | 8 | 10% |
| Unspecified | 5 | 6% |
| Other | 4 | 5% |
| Other | 19 | 24% |
| Unknown | 22 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Materials Science | 11 | 14% |
| Chemistry | 10 | 13% |
| Engineering | 7 | 9% |
| Biochemistry, Genetics and Molecular Biology | 6 | 8% |
| Unspecified | 5 | 6% |
| Other | 12 | 15% |
| Unknown | 29 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 01 May 2018.
All research outputs
#6,288,296
of 24,417,958 outputs
Outputs from Advanced Healthcare Materials
#1,016
of 2,694 outputs
Outputs of similar age
#120,336
of 450,632 outputs
Outputs of similar age from Advanced Healthcare Materials
#31
of 74 outputs
Altmetric has tracked 24,417,958 research outputs across all sources so far. This one has received more attention than most of these and is in the 73rd percentile.
So far Altmetric has tracked 2,694 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one has gotten more attention than average, scoring higher than 60% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 450,632 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 72% of its contemporaries.
We're also able to compare this research output to 74 others from the same source and published within six weeks on either side of this one. This one is in the 43rd percentile – i.e., 43% of its contemporaries scored the same or lower than it.