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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Trans-Reactivation: A New Epigenetic Phenomenon Underlying Transcriptional Reactivation of Silenced Genes
|
|---|---|
| Published in |
PLoS Genetics, August 2015
|
| DOI | 10.1371/journal.pgen.1005444 |
| Pubmed ID | |
| Authors |
Maria Cristina Onorati, Walter Arancio, Vincenzo Cavalieri, Antonia M. R. Ingrassia, Giulio Pavesi, Davide F. V. Corona |
| Abstract |
In order to study the role played by cellular RNA pools produced by homologous genomic loci in defining the transcriptional state of a silenced gene, we tested the effect of non-functional alleles of the white gene in the presence of a functional copy of white, silenced by heterochromatin. We found that non-functional alleles of white, unable to produce a coding transcript, could reactivate in trans the expression of a wild type copy of the same gene silenced by heterochromatin. This new epigenetic phenomenon of transcriptional trans-reactivation is heritable, relies on the presence of homologous RNA's and is affected by mutations in genes involved in post-transcriptional gene silencing. Our data suggest a general new unexpected level of gene expression control mediated by homologous RNA molecules in the context of heterochromatic genes. |
X Demographics
The data shown below were collected from the profiles of 21 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 48% |
| Canada | 2 | 10% |
| United Kingdom | 2 | 10% |
| France | 2 | 10% |
| Unknown | 5 | 24% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 48% |
| Scientists | 10 | 48% |
| Practitioners (doctors, other healthcare professionals) | 1 | 5% |
Mendeley readers
The data shown below were compiled from readership statistics for 42 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 7% |
| United Kingdom | 2 | 5% |
| Italy | 1 | 2% |
| Mexico | 1 | 2% |
| Netherlands | 1 | 2% |
| Unknown | 34 | 81% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 14 | 33% |
| Researcher | 10 | 24% |
| Student > Bachelor | 4 | 10% |
| Professor > Associate Professor | 4 | 10% |
| Student > Master | 2 | 5% |
| Other | 3 | 7% |
| Unknown | 5 | 12% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 26 | 62% |
| Biochemistry, Genetics and Molecular Biology | 10 | 24% |
| Computer Science | 1 | 2% |
| Unknown | 5 | 12% |
Attention Score in Context
This research output has an Altmetric Attention Score of 12. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 June 2016.
All research outputs
#3,064,580
of 25,393,528 outputs
Outputs from PLoS Genetics
#2,548
of 8,962 outputs
Outputs of similar age
#38,190
of 277,532 outputs
Outputs of similar age from PLoS Genetics
#40
of 174 outputs
Altmetric has tracked 25,393,528 research outputs across all sources so far. Compared to these this one has done well and is in the 87th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,962 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.8. This one has gotten more attention than average, scoring higher than 71% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 277,532 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 174 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.