| Title |
Role of Copper Dyshomeostasis in the Pathogenesis of Parkinson’s Disease
|
|---|---|
| Published in |
Bulletin of Experimental Biology and Medicine, March 2018
|
| DOI | 10.1007/s10517-018-4039-4 |
| Pubmed ID | |
| Authors |
M. N. Karpenko, E. Yu. Ilyicheva, Z. M. Muruzheva, I. V. Milyukhina, Yu. A. Orlov, L.V. Puchkova |
| Abstract |
Serum concentration of copper, immunoreactive polypeptides of ceruloplasmin and its oxidase activity, and the number of copper atoms per ceruloplasmin molecule were decreased in patients with Parkinson's disease in comparison with the corresponding parameters in age-matched healthy individuals, but the ratio of apoceruloplasmin to holoceruloplasmin in patients with Parkinson's disease was similar in both groups. Treatment of blood serum with Helex 100, a high-affinity copper chelator, revealed reduced content of labile copper atoms per ceruloplasmin molecule in patients with Parkinson's disease in comparison with that in healthy controls. The mechanism underlying impaired metabolic incorporation of labile copper atoms into CP molecule is discussed as a possible cause of copper dyshomeostasis associated with Parkinson's disease. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Canada | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Scientists | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 26 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 26 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 4 | 15% |
| Student > Ph. D. Student | 4 | 15% |
| Student > Master | 3 | 12% |
| Researcher | 2 | 8% |
| Professor | 1 | 4% |
| Other | 2 | 8% |
| Unknown | 10 | 38% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 3 | 12% |
| Nursing and Health Professions | 3 | 12% |
| Biochemistry, Genetics and Molecular Biology | 3 | 12% |
| Chemistry | 2 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 4% |
| Other | 4 | 15% |
| Unknown | 10 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#3,203,383
of 24,217,893 outputs
Outputs from Bulletin of Experimental Biology and Medicine
#38
of 1,357 outputs
Outputs of similar age
#65,132
of 333,866 outputs
Outputs of similar age from Bulletin of Experimental Biology and Medicine
#1
of 29 outputs
Altmetric has tracked 24,217,893 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,357 research outputs from this source. They receive a mean Attention Score of 2.3. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 333,866 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 80% of its contemporaries.
We're also able to compare this research output to 29 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 96% of its contemporaries.