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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Initiation of Meiotic Development Is Controlled by Three Posttranscriptional Pathways in Caenorhabditis elegans
|
|---|---|
| Published in |
Genetics, June 2018
|
| DOI | 10.1534/genetics.118.300985 |
| Pubmed ID | |
| Authors |
Ariz Mohammad, Kara Vanden Broek, Christopher Wang, Anahita Daryabeigi, Verena Jantsch, Dave Hansen, Tim Schedl |
| Abstract |
A major event in germline development is the transition from stem/progenitor cells to entry into meiosis and gametogenesis. This transition requires downregulation of mitotic cell cycle activity and upregulation of processes associated with meiosis. We identify the C. elegans SCFPROM-1 E3 ubiquitin ligase complex as functioning to downregulate mitotic cell cycle protein levels including CYE-1, WAPL-1 and KNL-2 at meiotic entry and, independently, promoting homologous chromosome pairing as a positive regulator of the CHK-2 kinase. SCFPROM-1 is thus a novel regulator of meiotic entry, coordinating downregulation of mitotic cell cycle proteins and promoting homolog pairing. We further show that SCFPROM-1 functions redundantly, in parallel to the previously described GLD-1 and GLD-2 meiotic entry pathways, downstream and inhibited by GLP-1 Notch signaling that specifies the stem cell fate. Accordingly, C. elegans employs three posttranscriptional pathways, SCFPROM-1 mediated protein degradation, GLD-1-mediated translational repression and GLD-2-mediated translational activation to control and coordinate the initiation of meiotic development. |
X Demographics
The data shown below were collected from the profiles of 8 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 25% |
| United States | 1 | 13% |
| Puerto Rico | 1 | 13% |
| Japan | 1 | 13% |
| Unknown | 3 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 7 | 88% |
| Scientists | 1 | 13% |
Mendeley readers
The data shown below were compiled from readership statistics for 52 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 52 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 10 | 19% |
| Student > Ph. D. Student | 8 | 15% |
| Student > Master | 8 | 15% |
| Other | 4 | 8% |
| Student > Bachelor | 2 | 4% |
| Other | 7 | 13% |
| Unknown | 13 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 19 | 37% |
| Agricultural and Biological Sciences | 13 | 25% |
| Environmental Science | 1 | 2% |
| Business, Management and Accounting | 1 | 2% |
| Immunology and Microbiology | 1 | 2% |
| Other | 2 | 4% |
| Unknown | 15 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 October 2018.
All research outputs
#8,266,724
of 25,385,509 outputs
Outputs from Genetics
#3,333
of 7,400 outputs
Outputs of similar age
#132,730
of 342,237 outputs
Outputs of similar age from Genetics
#51
of 69 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. This one has received more attention than most of these and is in the 66th percentile.
So far Altmetric has tracked 7,400 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.6. This one has gotten more attention than average, scoring higher than 54% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,237 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 60% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.