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The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation

Overview of attention for article published in Immunity, June 2018
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (97th percentile)
  • High Attention Score compared to outputs of the same age and source (90th percentile)

Mentioned by

news
10 news outlets
blogs
1 blog
twitter
46 X users

Citations

dimensions_citation
267 Dimensions

Readers on

mendeley
249 Mendeley
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Title
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation
Published in
Immunity, June 2018
DOI 10.1016/j.immuni.2018.04.032
Pubmed ID
Authors

Anke Di, Shiqin Xiong, Zhiming Ye, R.K. Subbarao Malireddi, Satoshi Kometani, Ming Zhong, Manish Mittal, Zhigang Hong, Thirumala-Devi Kanneganti, Jalees Rehman, Asrar B. Malik

Abstract

Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Here we identified the two-pore domain K+ channel (K2P) TWIK2 as the K+ efflux channel triggering NLRP3 inflammasome activation. Deletion of Kcnk6 (encoding TWIK2) prevented NLRP3 activation in macrophages and suppressed sepsis-induced lung inflammation. Adoptive transfer of Kcnk6-/- macrophages into mouse airways after macrophage depletion also prevented inflammatory lung injury. The K+ efflux channel TWIK2 in macrophages has a fundamental role in activating the NLRP3 inflammasome and consequently mediates inflammation, pointing to TWIK2 as a potential target for anti-inflammatory therapies.

X Demographics

X Demographics

The data shown below were collected from the profiles of 46 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 249 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 249 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 46 18%
Student > Master 32 13%
Researcher 29 12%
Student > Bachelor 20 8%
Professor > Associate Professor 13 5%
Other 37 15%
Unknown 72 29%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 44 18%
Immunology and Microbiology 38 15%
Agricultural and Biological Sciences 26 10%
Medicine and Dentistry 22 9%
Neuroscience 15 6%
Other 23 9%
Unknown 81 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 101. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 14 March 2022.
All research outputs
#419,528
of 25,385,509 outputs
Outputs from Immunity
#351
of 4,816 outputs
Outputs of similar age
#9,181
of 342,601 outputs
Outputs of similar age from Immunity
#6
of 63 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,816 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 33.3. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,601 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 97% of its contemporaries.
We're also able to compare this research output to 63 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 90% of its contemporaries.