Title |
The TWIK2 Potassium Efflux Channel in Macrophages Mediates NLRP3 Inflammasome-Induced Inflammation
|
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Published in |
Immunity, June 2018
|
DOI | 10.1016/j.immuni.2018.04.032 |
Pubmed ID | |
Authors |
Anke Di, Shiqin Xiong, Zhiming Ye, R.K. Subbarao Malireddi, Satoshi Kometani, Ming Zhong, Manish Mittal, Zhigang Hong, Thirumala-Devi Kanneganti, Jalees Rehman, Asrar B. Malik |
Abstract |
Potassium (K+) efflux across the plasma membrane is thought to be an essential mechanism for ATP-induced NLRP3 inflammasome activation, yet the identity of the efflux channel has remained elusive. Here we identified the two-pore domain K+ channel (K2P) TWIK2 as the K+ efflux channel triggering NLRP3 inflammasome activation. Deletion of Kcnk6 (encoding TWIK2) prevented NLRP3 activation in macrophages and suppressed sepsis-induced lung inflammation. Adoptive transfer of Kcnk6-/- macrophages into mouse airways after macrophage depletion also prevented inflammatory lung injury. The K+ efflux channel TWIK2 in macrophages has a fundamental role in activating the NLRP3 inflammasome and consequently mediates inflammation, pointing to TWIK2 as a potential target for anti-inflammatory therapies. |
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Geographical breakdown
Country | Count | As % |
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United States | 11 | 24% |
France | 3 | 7% |
United Kingdom | 3 | 7% |
Mexico | 2 | 4% |
Spain | 2 | 4% |
Pakistan | 1 | 2% |
Japan | 1 | 2% |
Denmark | 1 | 2% |
Australia | 1 | 2% |
Other | 2 | 4% |
Unknown | 19 | 41% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 31 | 67% |
Scientists | 11 | 24% |
Practitioners (doctors, other healthcare professionals) | 3 | 7% |
Science communicators (journalists, bloggers, editors) | 1 | 2% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 247 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 47 | 19% |
Student > Master | 32 | 13% |
Researcher | 29 | 12% |
Student > Bachelor | 20 | 8% |
Professor > Associate Professor | 12 | 5% |
Other | 35 | 14% |
Unknown | 72 | 29% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 44 | 18% |
Immunology and Microbiology | 36 | 15% |
Agricultural and Biological Sciences | 26 | 11% |
Medicine and Dentistry | 22 | 9% |
Neuroscience | 15 | 6% |
Other | 23 | 9% |
Unknown | 81 | 33% |