Title |
Two class I genes of the chicken MHC have different functions: BF1 is recognized by NK cells while BF2 is recognized by CTLs
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Published in |
Immunogenetics, June 2018
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DOI | 10.1007/s00251-018-1066-2 |
Pubmed ID | |
Authors |
Taejoong Kim, Henry D. Hunt, Mark S. Parcells, Vicky van Santen, Sandra J. Ewald |
Abstract |
The function of the chicken's major histocompatibility complex (MHC or B complex) class I major (BF2) and minor (BF1) glycoproteins is compared for their expression, ability to present viral antigens to cytotoxic T lymphocytes (CTLs), and interaction with natural killer (NK) cells. MHC-restricted CTLs recognized virus antigen in the context of the BF2*21 major glycoprotein but not the BF1*21 minor glycoprotein. Marek's disease virus (MDV), a large DNA virus known to reduce the cell surface expression of class I glycoprotein, reduced the expression of BF2 glycoprotein while BF1glycoprotein expressions are remained as no change or slight increase. In addition, the expression of BF1*21 class I glycoprotein protected target cells from NK cell lysis while the expression of the BF2*21 class I glycoprotein enhanced NK cell lysis of target cells. Therefore, BF1 and BF2 provide two different cellular immune functions; BF1 negatively regulates the NK cell killing activity and BF2 restricts the antigen specific CTL immune response. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 3 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 67% |
Scientists | 1 | 33% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Unknown | 18 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 6 | 33% |
Student > Ph. D. Student | 3 | 17% |
Student > Bachelor | 2 | 11% |
Student > Master | 2 | 11% |
Professor | 1 | 6% |
Other | 1 | 6% |
Unknown | 3 | 17% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 6 | 33% |
Agricultural and Biological Sciences | 4 | 22% |
Veterinary Science and Veterinary Medicine | 3 | 17% |
Social Sciences | 1 | 6% |
Unknown | 4 | 22% |