| Title |
GABA-B1 Receptor-Null Schwann Cells Exhibit Compromised In Vitro Myelination
|
|---|---|
| Published in |
Molecular Neurobiology, June 2018
|
| DOI | 10.1007/s12035-018-1158-x |
| Pubmed ID | |
| Authors |
Alessandro Faroni, Simona Melfi, Luca Franco Castelnovo, Veronica Bonalume, Deborah Colleoni, Paolo Magni, Marcos J. Araúzo-Bravo, Rolland Reinbold, Valerio Magnaghi |
| Abstract |
GABA-B receptors are important for Schwann cell (SC) commitment to a non-myelinating phenotype during development. However, the P0-GABA-B1fl/fl conditional knockout mice, lacking the GABA-B1 receptor specifically in SCs, also presented axon modifications, suggesting SC non-autonomous effects through the neuronal compartment. In this in vitro study, we evaluated whether the specific deletion of the GABA-B1 receptor in SCs may induce autonomous or non-autonomous cross-changes in sensory dorsal root ganglia (DRG) neurons. To this end, we performed an in vitro biomolecular and transcriptomic analysis of SC and DRG neuron primary cultures from P0-GABA-B1fl/fl mice. We found that cells from conditional P0-GABA-B1fl/fl mice exhibited proliferative, migratory and myelinating alterations. Moreover, we found transcriptomic changes in novel molecules that are involved in peripheral neuron-SC interaction. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 17 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 17 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 29% |
| Student > Doctoral Student | 2 | 12% |
| Researcher | 2 | 12% |
| Student > Bachelor | 1 | 6% |
| Unspecified | 1 | 6% |
| Other | 2 | 12% |
| Unknown | 4 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 41% |
| Agricultural and Biological Sciences | 3 | 18% |
| Unspecified | 1 | 6% |
| Veterinary Science and Veterinary Medicine | 1 | 6% |
| Medicine and Dentistry | 1 | 6% |
| Other | 0 | 0% |
| Unknown | 4 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 June 2018.
All research outputs
#15,683,389
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Outputs from Molecular Neurobiology
#2,099
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Outputs of similar age
#209,534
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Outputs of similar age from Molecular Neurobiology
#73
of 122 outputs
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