Title |
Regulation of renal phosphate handling: inter-organ communication in health and disease
|
---|---|
Published in |
Journal of Bone and Mineral Metabolism, August 2015
|
DOI | 10.1007/s00774-015-0705-z |
Pubmed ID | |
Authors |
Sawako Tatsumi, Atsumi Miyagawa, Ichiro Kaneko, Yuji Shiozaki, Hiroko Segawa, Ken-ichi Miyamoto |
Abstract |
In this review, we focus on the interconnection of inorganic phosphate (Pi) homeostasis in the network of the bone-kidney, parathyroid-kidney, intestine-kidney, and liver-kidney axes. Such a network of organ communication is important for body Pi homeostasis. Normalization of serum Pi levels is a clinical target in patients with chronic kidney disease (CKD). Particularly, disorders of the fibroblast growth factor 23/klotho system are observed in early CKD. Identification of phosphaturic factors from the intestine and liver may enhance our understanding of body Pi homeostasis and Pi metabolism disturbances in CKD patients. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Netherlands | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 26 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 5 | 19% |
Researcher | 4 | 15% |
Student > Bachelor | 3 | 12% |
Other | 1 | 4% |
Student > Doctoral Student | 1 | 4% |
Other | 2 | 8% |
Unknown | 10 | 38% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 5 | 19% |
Agricultural and Biological Sciences | 3 | 12% |
Biochemistry, Genetics and Molecular Biology | 2 | 8% |
Nursing and Health Professions | 2 | 8% |
Immunology and Microbiology | 1 | 4% |
Other | 2 | 8% |
Unknown | 11 | 42% |