You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output.
Click here to find out more.
X Demographics
Mendeley readers
Attention Score in Context
| Title |
Toxoplasma Parasite Twisting Motion Mechanically Induces Host Cell Membrane Fission to Complete Invasion within a Protective Vacuole
|
|---|---|
| Published in |
Cell Host & Microbe (Science Direct), June 2018
|
| DOI | 10.1016/j.chom.2018.06.003 |
| Pubmed ID | |
| Authors |
Georgios Pavlou, Mateusz Biesaga, Bastien Touquet, Vanessa Lagal, Martial Balland, Alexandre Dufour, Mohamed-ali Hakimi, Isabelle Tardieux |
| Abstract |
To invade cells, the parasite Toxoplasma gondii injects a multi-unit nanodevice into the target cell plasma membrane (PM). The core nanodevice, which is composed of the RhOptry Neck (RON) protein complex, connects Toxoplasma and host cell through a circular tight junction (TJ). We now report that this RON nanodevice mechanically promotes membrane scission at the TJ-PM interface, directing a physical rotation driven by the parasite twisting motion that enables the budding parasitophorous vacuole (PV) to seal and separate from the host cell PM as a bona fide subcellular Toxoplasma-loaded PV. Mechanically impairing the process induces swelling of the budding PV and death of the parasite but not host cell. Moreover, this study reveals that the parasite nanodevice functions as a molecular trigger to promote PV membrane remodeling and rapid onset of T. gondii to intracellular lifestyle. |
X Demographics
The data shown below were collected from the profiles of 50 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 13 | 26% |
| United Kingdom | 8 | 16% |
| France | 6 | 12% |
| Germany | 2 | 4% |
| Mexico | 1 | 2% |
| Canada | 1 | 2% |
| Chile | 1 | 2% |
| Mozambique | 1 | 2% |
| Spain | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 15 | 30% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 27 | 54% |
| Scientists | 19 | 38% |
| Science communicators (journalists, bloggers, editors) | 2 | 4% |
| Practitioners (doctors, other healthcare professionals) | 2 | 4% |
Mendeley readers
The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 84 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 25% |
| Student > Bachelor | 13 | 15% |
| Researcher | 11 | 13% |
| Student > Master | 9 | 11% |
| Student > Doctoral Student | 5 | 6% |
| Other | 7 | 8% |
| Unknown | 18 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 18 | 21% |
| Agricultural and Biological Sciences | 18 | 21% |
| Immunology and Microbiology | 14 | 17% |
| Engineering | 4 | 5% |
| Chemistry | 3 | 4% |
| Other | 7 | 8% |
| Unknown | 20 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 61. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 February 2020.
All research outputs
#716,827
of 25,746,891 outputs
Outputs from Cell Host & Microbe (Science Direct)
#517
of 2,652 outputs
Outputs of similar age
#15,420
of 343,957 outputs
Outputs of similar age from Cell Host & Microbe (Science Direct)
#19
of 58 outputs
Altmetric has tracked 25,746,891 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,652 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 51.8. This one has done well, scoring higher than 80% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 343,957 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 58 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 67% of its contemporaries.