| Title |
Mechanism, factors, and physiological role of nonsense-mediated mRNA decay
|
|---|---|
| Published in |
Cellular and Molecular Life Sciences, August 2015
|
| DOI | 10.1007/s00018-015-2017-9 |
| Pubmed ID | |
| Authors |
Tobias Fatscher, Volker Boehm, Niels H. Gehring |
| Abstract |
Nonsense-mediated mRNA decay (NMD) is a translation-dependent, multistep process that degrades irregular or faulty messenger RNAs (mRNAs). NMD mainly targets mRNAs with a truncated open reading frame (ORF) due to premature termination codons (PTCs). In addition, NMD also regulates the expression of different types of endogenous mRNA substrates. A multitude of factors are involved in the tight regulation of the NMD mechanism. In this review, we focus on the molecular mechanism of mammalian NMD. Based on the published data, we discuss the involvement of translation termination in NMD initiation. Furthermore, we provide a detailed overview of the core NMD machinery, as well as several peripheral NMD factors, and discuss their function. Finally, we present an overview of diseases associated with NMD factor mutations and summarize the current state of treatment for genetic disorders caused by nonsense mutations. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 156 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | <1% |
| Germany | 1 | <1% |
| Switzerland | 1 | <1% |
| Unknown | 153 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 37 | 24% |
| Researcher | 25 | 16% |
| Student > Master | 18 | 12% |
| Student > Bachelor | 16 | 10% |
| Student > Doctoral Student | 15 | 10% |
| Other | 25 | 16% |
| Unknown | 20 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 53 | 34% |
| Agricultural and Biological Sciences | 49 | 31% |
| Medicine and Dentistry | 11 | 7% |
| Neuroscience | 5 | 3% |
| Unspecified | 4 | 3% |
| Other | 11 | 7% |
| Unknown | 23 | 15% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 August 2015.
All research outputs
#16,031,680
of 23,794,258 outputs
Outputs from Cellular and Molecular Life Sciences
#3,071
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Outputs of similar age
#158,613
of 267,519 outputs
Outputs of similar age from Cellular and Molecular Life Sciences
#38
of 56 outputs
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