Title |
Mechanism, factors, and physiological role of nonsense-mediated mRNA decay
|
---|---|
Published in |
Cellular and Molecular Life Sciences, August 2015
|
DOI | 10.1007/s00018-015-2017-9 |
Pubmed ID | |
Authors |
Tobias Fatscher, Volker Boehm, Niels H. Gehring |
Abstract |
Nonsense-mediated mRNA decay (NMD) is a translation-dependent, multistep process that degrades irregular or faulty messenger RNAs (mRNAs). NMD mainly targets mRNAs with a truncated open reading frame (ORF) due to premature termination codons (PTCs). In addition, NMD also regulates the expression of different types of endogenous mRNA substrates. A multitude of factors are involved in the tight regulation of the NMD mechanism. In this review, we focus on the molecular mechanism of mammalian NMD. Based on the published data, we discuss the involvement of translation termination in NMD initiation. Furthermore, we provide a detailed overview of the core NMD machinery, as well as several peripheral NMD factors, and discuss their function. Finally, we present an overview of diseases associated with NMD factor mutations and summarize the current state of treatment for genetic disorders caused by nonsense mutations. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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United Kingdom | 1 | <1% |
Germany | 1 | <1% |
Switzerland | 1 | <1% |
Unknown | 153 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 37 | 24% |
Researcher | 25 | 16% |
Student > Master | 18 | 12% |
Student > Bachelor | 16 | 10% |
Student > Doctoral Student | 15 | 10% |
Other | 25 | 16% |
Unknown | 20 | 13% |
Readers by discipline | Count | As % |
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Biochemistry, Genetics and Molecular Biology | 53 | 34% |
Agricultural and Biological Sciences | 49 | 31% |
Medicine and Dentistry | 11 | 7% |
Neuroscience | 5 | 3% |
Unspecified | 4 | 3% |
Other | 11 | 7% |
Unknown | 23 | 15% |