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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Noncatalytic PTEN missense mutation predisposes to organ-selective cancer development in vivo
|
|---|---|
| Published in |
Genes & Development, August 2015
|
| DOI | 10.1101/gad.262568.115 |
| Pubmed ID | |
| Authors |
Enrico Caserta, Onur Egriboz, Hui Wang, Chelsea Martin, Christopher Koivisto, Thierry Pecót, Raleigh D. Kladney, Changxian Shen, Kang-Sup Shim, Thac Pham, Matthew K. Karikomi, Melissa J. Mauntel, Sarmila Majumder, Maria C. Cuitino, Xing Tang, Arunima Srivastava, Lianbo Yu, Julie Wallace, Xiaokui Mo, Morag Park, Soledad A. Fernandez, Robert Pilarski, Krista M.D. La Perle, Thomas J. Rosol, Vincenzo Coppola, Diego H. Castrillon, Cynthia Timmers, David E. Cohn, David M. O'Malley, Floor Backes, Adrian A. Suarez, Paul Goodfellow, Helen M. Chamberlin, Erin R. Macrae, Charles L. Shapiro, Michael C. Ostrowski, Gustavo Leone |
| Abstract |
Inactivation of phosphatase and tensin homology deleted on chromosome 10 (PTEN) is linked to increased PI3K-AKT signaling, enhanced organismal growth, and cancer development. Here we generated and analyzed Pten knock-in mice harboring a C2 domain missense mutation at phenylalanine 341 (Pten(FV)), found in human cancer. Despite having reduced levels of PTEN protein, homozygous Pten(FV/FV) embryos have intact AKT signaling, develop normally, and are carried to term. Heterozygous Pten(FV/+) mice develop carcinoma in the thymus, stomach, adrenal medulla, and mammary gland but not in other organs typically sensitive to Pten deficiency, including the thyroid, prostate, and uterus. Progression to carcinoma in sensitive organs ensues in the absence of overt AKT activation. Carcinoma in the uterus, a cancer-resistant organ, requires a second clonal event associated with the spontaneous activation of AKT and downstream signaling. In summary, this PTEN noncatalytic missense mutation exposes a core tumor suppressor function distinct from inhibition of canonical AKT signaling that predisposes to organ-selective cancer development in vivo. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 50% |
| Unknown | 1 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Scientists | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 63 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 63 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 14 | 22% |
| Student > Ph. D. Student | 11 | 17% |
| Other | 8 | 13% |
| Student > Bachelor | 5 | 8% |
| Student > Master | 4 | 6% |
| Other | 13 | 21% |
| Unknown | 8 | 13% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 20 | 32% |
| Medicine and Dentistry | 10 | 16% |
| Agricultural and Biological Sciences | 10 | 16% |
| Computer Science | 3 | 5% |
| Engineering | 3 | 5% |
| Other | 7 | 11% |
| Unknown | 10 | 16% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 September 2015.
All research outputs
#15,330,390
of 23,577,654 outputs
Outputs from Genes & Development
#5,059
of 5,881 outputs
Outputs of similar age
#149,764
of 268,182 outputs
Outputs of similar age from Genes & Development
#35
of 51 outputs
Altmetric has tracked 23,577,654 research outputs across all sources so far. This one is in the 32nd percentile – i.e., 32% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,881 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.8. This one is in the 12th percentile – i.e., 12% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 268,182 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 51 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.