| Title |
Cannabinoids, endocannabinoids, and cancer
|
|---|---|
| Published in |
Cancer and Metastasis Reviews, October 2011
|
| DOI | 10.1007/s10555-011-9318-8 |
| Pubmed ID | |
| Authors |
Daniel J. Hermanson, Lawrence J. Marnett |
| Abstract |
The endocannabinoid system consists of an array of endogenously produced bioactive lipids that activate cannabinoid receptors. Although the primary focus of endocannabinoid biology has been on neurological and psychiatric effects, recent work has revealed several important interactions between the endocannabinoid system and cancer. Several different types of cancer have abnormal regulation of the endocannabinoid system that contributes to cancer progression and correlates to clinical outcomes. Modulation of the endocannabinoid system by pharmacological agents in various cancer types reveals that it can mediate antiproliferative and apoptotic effects by both cannabinoid receptor-dependent and -independent pathways. Selective agonists and antagonists of the cannabinoid receptors, inhibitors of endocannabinoid hydrolysis, and cannabinoid analogs have been utilized to probe the pathways involved in the effects of the endocannabinoid system on cancer cell apoptosis, proliferation, migration, adhesion, and invasion. The antiproliferative and apoptotic effects produced by some of these pharmacological probes reveal that the endocannabinoid system is a promising new target for the development of novel chemotherapeutics to treat cancer. |
X Demographics
The data shown below were collected from the profiles of 85 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 17 | 20% |
| Canada | 8 | 9% |
| United Kingdom | 4 | 5% |
| Germany | 3 | 4% |
| Pakistan | 1 | 1% |
| Argentina | 1 | 1% |
| Switzerland | 1 | 1% |
| India | 1 | 1% |
| Sweden | 1 | 1% |
| Other | 3 | 4% |
| Unknown | 45 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 70 | 82% |
| Practitioners (doctors, other healthcare professionals) | 10 | 12% |
| Scientists | 3 | 4% |
| Science communicators (journalists, bloggers, editors) | 1 | 1% |
| Unknown | 1 | 1% |
Mendeley readers
The data shown below were compiled from readership statistics for 240 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 5 | 2% |
| Brazil | 2 | <1% |
| United Kingdom | 2 | <1% |
| Spain | 2 | <1% |
| Russia | 1 | <1% |
| Puerto Rico | 1 | <1% |
| Croatia | 1 | <1% |
| Unknown | 226 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 39 | 16% |
| Student > Bachelor | 36 | 15% |
| Researcher | 30 | 13% |
| Student > Master | 30 | 13% |
| Other | 17 | 7% |
| Other | 42 | 18% |
| Unknown | 46 | 19% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 43 | 18% |
| Agricultural and Biological Sciences | 42 | 18% |
| Biochemistry, Genetics and Molecular Biology | 36 | 15% |
| Chemistry | 20 | 8% |
| Pharmacology, Toxicology and Pharmaceutical Science | 14 | 6% |
| Other | 30 | 13% |
| Unknown | 55 | 23% |
Attention Score in Context
This research output has an Altmetric Attention Score of 95. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 November 2023.
All research outputs
#444,250
of 25,312,451 outputs
Outputs from Cancer and Metastasis Reviews
#8
of 872 outputs
Outputs of similar age
#1,571
of 146,309 outputs
Outputs of similar age from Cancer and Metastasis Reviews
#3
of 19 outputs
Altmetric has tracked 25,312,451 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 872 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.7. This one has done particularly well, scoring higher than 99% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 146,309 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 19 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 89% of its contemporaries.