| Title |
Hypoglycemia and risk of vascular events and mortality: a systematic review and meta-analysis
|
|---|---|
| Published in |
Acta Diabetologica, August 2015
|
| DOI | 10.1007/s00592-015-0803-3 |
| Pubmed ID | |
| Authors |
Jong Shiuan Yeh, Shih-Hsien Sung, Hui-Mei Huang, Huei-Ling Yang, Li-Kai You, Shao-Yuan Chuang, Po-Chieh Huang, Pai-Feng Hsu, Hao-Min Cheng, Chen-Huan Chen |
| Abstract |
Hypoglycemia has been associated with adverse outcomes in patients with diabetes and critical illness. However, such associations in these populations have not been systematically examined. We conducted a systematic review and meta-analysis of longitudinal follow-up cohort studies to investigate the associations between hypoglycemia and various adverse outcomes. After removing duplicates and critically appraising all screened citations, a total of 19 eligible studies were included. As demonstrated by random-effects meta-analysis, hypoglycemia was strongly associated with a higher risk of adverse events (HR 1.90, 95 % CI 1.63-2.20; P < 0.001). Comparable risk ratios were shown in prespecified stratified analyses investigating above association for different study endpoints, in patients with or without critical illness, in patients with and without diabetes (from 1.47 to 3.31; p for interaction or heterogeneity >0.1). Additionally, a dose-dependent relationship between the severity of hypoglycemia and adverse vascular events and mortality (HR for mild hypoglycemia: 1.68, 95 % CI 1.25-2.26; P < 0.001 and HR for severe hypoglycemia: 2.33, 95 % CI 2.07-2.61; P < 0.001; p for trend 0.02) was observed. Suggested by a bias analysis, the above observations were unlikely to have resulted from unmeasured confounding parameters. This is the first study demonstrating that hypoglycemia was associated with comparable risk ratios in different study populations and various study endpoints, and a trend of a dose-dependent relationship between hypoglycemia severity and adverse events. The findings of this systematic review support the speculation that hypoglycemia is a risk factor for adverse vascular events and mortality. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 2 | 3% |
| Unknown | 60 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Other | 7 | 11% |
| Researcher | 7 | 11% |
| Student > Master | 7 | 11% |
| Student > Ph. D. Student | 6 | 10% |
| Student > Postgraduate | 6 | 10% |
| Other | 14 | 23% |
| Unknown | 15 | 24% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 23 | 37% |
| Nursing and Health Professions | 5 | 8% |
| Sports and Recreations | 3 | 5% |
| Biochemistry, Genetics and Molecular Biology | 2 | 3% |
| Economics, Econometrics and Finance | 2 | 3% |
| Other | 9 | 15% |
| Unknown | 18 | 29% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 August 2015.
All research outputs
#20,288,585
of 22,824,164 outputs
Outputs from Acta Diabetologica
#723
of 893 outputs
Outputs of similar age
#224,691
of 267,539 outputs
Outputs of similar age from Acta Diabetologica
#10
of 13 outputs
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