Title |
Conservative or radical surgery for pediatric papillary thyroid carcinoma: A systematic review of the literature
|
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Published in |
International Journal of Pediatric Otorhinolaryngology, August 2015
|
DOI | 10.1016/j.ijporl.2015.08.004 |
Pubmed ID | |
Authors |
Xi Jin, Liam Masterson, Anant Patel, Liz Hook, James Nicholson, Sarah Jefferies, Mark Gaze, Ramez Nassif, Robert Eller, Tony Hulse, Piyush Jani |
Abstract |
Pediatric papillary thyroid carcinoma (PTC) is characterized by an aggressive clinical course. Early diagnosis is a challenge and treatment consists principally of partial or total thyroidectomy±neck dissection and radioactive iodine therapy. Due to the rarity of PTC in children, there is no consensus on optimal surgical treatment. A literature search was carried out using PubMed, Embase, Medline, Cochrane and Web of Science. Seven studies (489 patients) investigating the outcome of surgically managed pediatric PTC were identified. No clear advantage in survival or recurrence rate was found for total thyroidectomy compared to other surgical approaches. Despite the aggressive behavior of PTC, prognosis is good, with low mortality. After removal of disease and prevention of recurrence, reduction of iatrogenic complications are a priority in this age group. Due to the paucity of available evidence, this review cannot recommend conservative or radical surgery for pediatric papillary thyroid carcinoma. To answer this question, we recommend the establishment of a randomized controlled trial with adequately matched baseline variables. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Unknown | 1 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Ecuador | 1 | 2% |
Unknown | 60 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 9 | 15% |
Student > Master | 7 | 11% |
Other | 6 | 10% |
Student > Postgraduate | 6 | 10% |
Researcher | 4 | 7% |
Other | 12 | 20% |
Unknown | 17 | 28% |
Readers by discipline | Count | As % |
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Medicine and Dentistry | 27 | 44% |
Biochemistry, Genetics and Molecular Biology | 3 | 5% |
Nursing and Health Professions | 2 | 3% |
Agricultural and Biological Sciences | 2 | 3% |
Pharmacology, Toxicology and Pharmaceutical Science | 2 | 3% |
Other | 7 | 11% |
Unknown | 18 | 30% |