| Title |
Origin of Reparative Stem Cells in Fracture Healing
|
|---|---|
| Published in |
Current Osteoporosis Reports, June 2018
|
| DOI | 10.1007/s11914-018-0458-4 |
| Pubmed ID | |
| Authors |
Beth C. Bragdon, Chelsea S. Bahney |
| Abstract |
The identity and functional roles of stem cell population(s) that contribute to fracture repair remains unclear. This review provides a brief history of mesenchymal stem cell (MSCs) and provides an updated view of the many stem/progenitor cell populations contributing to fracture repair. Functional studies show MSCs are not the multipotential stem cell population that form cartilage and bone during fracture repair. Rather, multiple studies have confirmed the periosteum is the primary source of stem/progenitor cells for fracture repair. Newer work is also identifying other stem/progenitor cells that may also contribute to healing. Although the heterogenous periosteal cells migrate to the fracture site and contribute directly to callus formation, other cell populations are involved. Pericytes and bone marrow stromal cells are now thought of as key secretory centers that mostly coordinate the repair process. Other populations of stem/progenitor cells from the muscle and transdifferentiated chondroctyes may also contribute to repair, and their functional role is an area of active research. |
X Demographics
The data shown below were collected from the profiles of 16 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 63% |
| Netherlands | 1 | 6% |
| France | 1 | 6% |
| Australia | 1 | 6% |
| Unknown | 3 | 19% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 11 | 69% |
| Scientists | 5 | 31% |
Mendeley readers
The data shown below were compiled from readership statistics for 62 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 62 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 16 | 26% |
| Student > Bachelor | 9 | 15% |
| Student > Master | 7 | 11% |
| Researcher | 6 | 10% |
| Student > Doctoral Student | 5 | 8% |
| Other | 5 | 8% |
| Unknown | 14 | 23% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 16 | 26% |
| Biochemistry, Genetics and Molecular Biology | 10 | 16% |
| Agricultural and Biological Sciences | 6 | 10% |
| Engineering | 4 | 6% |
| Immunology and Microbiology | 2 | 3% |
| Other | 5 | 8% |
| Unknown | 19 | 31% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 June 2019.
All research outputs
#2,987,811
of 23,092,602 outputs
Outputs from Current Osteoporosis Reports
#60
of 550 outputs
Outputs of similar age
#63,582
of 329,246 outputs
Outputs of similar age from Current Osteoporosis Reports
#2
of 13 outputs
Altmetric has tracked 23,092,602 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 550 research outputs from this source. They receive a mean Attention Score of 4.8. This one has done well, scoring higher than 89% of its peers.
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We're also able to compare this research output to 13 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.