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Mendeley readers
Attention Score in Context
| Title |
Focused Ultrasound Enabled Trans‐Blood Brain Barrier Delivery of Gold Nanoclusters: Effect of Surface Charges and Quantification Using Positron Emission Tomography
|
|---|---|
| Published in |
Small, July 2018
|
| DOI | 10.1002/smll.201703115 |
| Pubmed ID | |
| Authors |
Deborah Sultan, Dezhuang Ye, Gyu Seong Heo, Xiaohui Zhang, Hannah Luehmann, Yimei Yue, Lisa Detering, Sergey Komarov, Sara Taylor, Yuan‐Chuan Tai, Joshua B. Rubin, Hong Chen, Yongjian Liu |
| Abstract |
Focused ultrasound (FUS) technology is reported to enhance the delivery of 64 Cu-integrated ultrasmall gold nanoclusters (64 Cu-AuNCs) across the blood-brain barrier (BBB) as measured by positron emission tomography (PET). To better define the optimal physical properties for brain delivery, 64 Cu-AuNCs with different surface charges are synthesized and characterized. In vivo biodistribution studies are performed to compare the individual organ uptake of each type of 64 Cu-AuNCs. Quantitative PET imaging post-FUS treatment shows site-targeted brain penetration, retention, and diffusion of the negative, neutral, and positive 64 Cu-AuNCs. Autoradiography is performed to compare the intrabrain distribution of these nanoclusters. PET Imaging demonstrates the effective BBB opening and successful delivery of 64 Cu-AuNCs into the brain. Of the three 64 Cu-AuNCs investigated, the neutrally charged nanostructure performs the best and is the candidate platform for future theranostic applications in neuro-oncology. |
X Demographics
The data shown below were collected from the profiles of 3 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 33% |
| Unknown | 2 | 67% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 67% |
| Scientists | 1 | 33% |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 41 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 12 | 29% |
| Researcher | 5 | 12% |
| Student > Master | 4 | 10% |
| Student > Postgraduate | 3 | 7% |
| Professor | 2 | 5% |
| Other | 6 | 15% |
| Unknown | 9 | 22% |
| Readers by discipline | Count | As % |
|---|---|---|
| Engineering | 7 | 17% |
| Agricultural and Biological Sciences | 4 | 10% |
| Chemistry | 4 | 10% |
| Neuroscience | 3 | 7% |
| Medicine and Dentistry | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 15 | 37% |
Attention Score in Context
This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#14,883,484
of 23,094,276 outputs
Outputs from Small
#3,586
of 6,660 outputs
Outputs of similar age
#195,904
of 327,941 outputs
Outputs of similar age from Small
#66
of 121 outputs
Altmetric has tracked 23,094,276 research outputs across all sources so far. This one is in the 34th percentile – i.e., 34% of other outputs scored the same or lower than it.
So far Altmetric has tracked 6,660 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,941 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 39th percentile – i.e., 39% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 121 others from the same source and published within six weeks on either side of this one. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.