| Title |
microRNAs Modulate Spatial Memory in the Hippocampus and in the Ventral Striatum in a Region-Specific Manner
|
|---|---|
| Published in |
Molecular Neurobiology, August 2015
|
| DOI | 10.1007/s12035-015-9398-5 |
| Pubmed ID | |
| Authors |
F. Capitano, J. Camon, V. Ferretti, V. Licursi, F. De Vito, A. Rinaldi, S. Vincenti, C. Mannironi, P. Fragapane, I. Bozzoni, A. Oliverio, R. Negri, C. Presutti, Andrea Mele |
| Abstract |
MicroRNAs are endogenous, noncoding RNAs crucial for the post-transcriptional regulation of gene expression. Their role in spatial memory formation, however, is poorly explored. In this study, we analyzed learning-induced microRNA expression in the hippocampus and in the ventral striatum. Among miRNAs specifically downregulated by spatial training, we focused on the hippocampus-specific miR-324-5p and the ventral striatum-specific miR-24. In vivo overexpression of the two miRNAs demonstrated that miR-324-5p is able to impair memory if administered in the hippocampus but not in the ventral striatum, while the opposite is true for miR-24. Overall, these findings demonstrate a causal relationship between miRNA expression changes and spatial memory formation. Furthermore, they provide support for a regional dissociation in the post-transcriptional processes underlying spatial memory in the two brain structures analyzed. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 30 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 30 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 23% |
| Student > Ph. D. Student | 5 | 17% |
| Professor > Associate Professor | 3 | 10% |
| Professor | 2 | 7% |
| Student > Doctoral Student | 2 | 7% |
| Other | 2 | 7% |
| Unknown | 9 | 30% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 7 | 23% |
| Biochemistry, Genetics and Molecular Biology | 5 | 17% |
| Agricultural and Biological Sciences | 5 | 17% |
| Psychology | 2 | 7% |
| Medicine and Dentistry | 1 | 3% |
| Other | 1 | 3% |
| Unknown | 9 | 30% |
Attention Score in Context
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#20,290,425
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Outputs from Molecular Neurobiology
#2,792
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Outputs of similar age from Molecular Neurobiology
#75
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