| Title |
Self- and informant-rated apathy in patients with childhood-onset craniopharyngioma
|
|---|---|
| Published in |
Journal of Neuro-Oncology, July 2018
|
| DOI | 10.1007/s11060-018-2936-z |
| Pubmed ID | |
| Authors |
Aylin Mehren, Jale Özyurt, Paula zu Klampen, Svenja Boekhoff, Christiane M. Thiel, Hermann L. Müller |
| Abstract |
The current study aimed to assess whether childhood-onset craniopharyngioma patients suffer from symptoms of apathy, as assessed by patients themselves and their close others. We further analyzed whether apathy scores are related to symptoms of depression. Childhood-onset craniopharyngioma patients (n = 35, 16 female, median age = 22) and matched healthy controls (n = 35, 19 female, median age = 21) were asked to complete self-ratings of the Apathy Evaluation Scale, whereas informant-ratings were obtained from their close others. Depression was assessed by self-ratings using the German version of the Center for Epidemiological Studies Depression Scale. As primary outcome measures, self- and informant-rated apathy scores were compared between patients and healthy controls. As secondary outcome measures, differences between self- and informant-rated apathy within the single groups and associations between apathy and depression were analyzed. Compared to healthy controls, patients displayed significantly higher apathy levels in informant-ratings (medianpatients = 18, mediancontrols = 12, p = .021), but not in self-ratings (medianpatients = 11, mediancontrols =12, p = .68). In patients, there was a significant discrepancy between self- and informant-rated apathy and self-rated apathy was related to symptoms of depression. This is the first study to show that childhood-onset craniopharyngioma patients may be at high risk for apathy. Noteworthy, apathy levels in the patient group were judged to be high by their close others but not by the patients themselves, indicating that many patients were not fully aware of their impairments. As apathy is associated with numerous adverse outcomes affecting everyday life and vocational opportunities, future investigations are needed to identify specific risk factors for apathy. Clinical Trial Registration No: NCT00258453. |
X Demographics
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Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 29 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 29 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 6 | 21% |
| Librarian | 2 | 7% |
| Student > Doctoral Student | 1 | 3% |
| Student > Bachelor | 1 | 3% |
| Other | 1 | 3% |
| Other | 4 | 14% |
| Unknown | 14 | 48% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 4 | 14% |
| Medicine and Dentistry | 3 | 10% |
| Nursing and Health Professions | 1 | 3% |
| Physics and Astronomy | 1 | 3% |
| Social Sciences | 1 | 3% |
| Other | 3 | 10% |
| Unknown | 16 | 55% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 03 July 2018.
All research outputs
#20,525,274
of 23,094,276 outputs
Outputs from Journal of Neuro-Oncology
#2,592
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#287,390
of 327,912 outputs
Outputs of similar age from Journal of Neuro-Oncology
#54
of 72 outputs
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