| Title |
In Vivo Reactive Oxygen Species Detection With a Novel Positron Emission Tomography Tracer, 18F-DHMT, Allows for Early Detection of Anthracycline-Induced Cardiotoxicity in Rodents
|
|---|---|
| Published in |
JACC: Basic to Translational Science, May 2018
|
| DOI | 10.1016/j.jacbts.2018.02.003 |
| Pubmed ID | |
| Authors |
Nabil E. Boutagy, Jing Wu, Zhengxi Cai, Wenjie Zhang, Carmen J. Booth, Tassos C. Kyriakides, Daniel Pfau, Tim Mulnix, Zhao Liu, Edward J. Miller, Lawrence H. Young, Richard E. Carson, Yiyun Huang, Chi Liu, Albert J. Sinusas |
| Abstract |
Reactive oxygen species (ROS) are involved in doxorubicin-induced cardiotoxicity. The authors investigated the efficacy of 18F-DHMT, a marker of ROS, for early detection of doxorubicin-induced cardiotoxicity in rats. Echocardiography was performed at baseline and 4, 6, and 8 weeks post-doxorubicin initiation, whereas in vivo superoxide production was measured at 4 and 6 weeks with 18F-DHMT positron emission tomography. Left ventricular ejection fraction (LVEF) was not significantly decreased until 6 weeks post-doxorubicin treatment, whereas myocardial superoxide production was significantly elevated at 4 weeks. 18F-DHMT imaging detected an elevation in cardiac superoxide production before a fall in LVEF in rodents and may allow for early cardiotoxicity detection in cancer patients. |
X Demographics
The data shown below were collected from the profiles of 102 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 19 | 19% |
| Spain | 8 | 8% |
| Argentina | 5 | 5% |
| Italy | 4 | 4% |
| Brazil | 4 | 4% |
| Mexico | 4 | 4% |
| Canada | 2 | 2% |
| Australia | 2 | 2% |
| Venezuela, Bolivarian Republic of | 2 | 2% |
| Other | 17 | 17% |
| Unknown | 35 | 34% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 72 | 71% |
| Practitioners (doctors, other healthcare professionals) | 14 | 14% |
| Scientists | 10 | 10% |
| Science communicators (journalists, bloggers, editors) | 6 | 6% |
Mendeley readers
The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 34 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 26% |
| Researcher | 5 | 15% |
| Student > Bachelor | 3 | 9% |
| Student > Postgraduate | 2 | 6% |
| Librarian | 1 | 3% |
| Other | 2 | 6% |
| Unknown | 12 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Chemistry | 9 | 26% |
| Medicine and Dentistry | 3 | 9% |
| Biochemistry, Genetics and Molecular Biology | 2 | 6% |
| Nursing and Health Professions | 2 | 6% |
| Pharmacology, Toxicology and Pharmaceutical Science | 1 | 3% |
| Other | 4 | 12% |
| Unknown | 13 | 38% |
Attention Score in Context
This research output has an Altmetric Attention Score of 67. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 June 2022.
All research outputs
#651,122
of 25,746,891 outputs
Outputs from JACC: Basic to Translational Science
#49
of 822 outputs
Outputs of similar age
#14,129
of 345,359 outputs
Outputs of similar age from JACC: Basic to Translational Science
#5
of 22 outputs
Altmetric has tracked 25,746,891 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 822 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.1. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 345,359 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 95% of its contemporaries.
We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 77% of its contemporaries.