| Title |
The Effect of Melatonin on Behavioral, Molecular, and Histopathological Changes in Cuprizone Model of Demyelination
|
|---|---|
| Published in |
Molecular Neurobiology, August 2015
|
| DOI | 10.1007/s12035-015-9404-y |
| Pubmed ID | |
| Authors |
Gelareh Vakilzadeh, Fariba Khodagholi, Tahereh Ghadiri, Amir Ghaemi, Farshid Noorbakhsh, Mohammad Sharifzadeh, Ali Gorji |
| Abstract |
Multiple sclerosis (MS) is an autoimmune, demyelinating disease of the central nervous system. The protective effects of melatonin (MLT) on various neurodegenerative diseases, including MS, have been suggested. In the present study, we examined the effect of MLT on demyelination, apoptosis, inflammation, and behavioral dysfunctions in the cuprizone toxic model of demyelination. C57BL/6J mice were fed a chaw containing 0.2 % cuprizone for 5 weeks and received two doses of MLT (50 and 100 mg/kg) intraperitoneally for the last 7 days of cuprizone diet. Administration of MLT improved motor behavior deficits induced by cuprizone diet. MLT dose-dependently decreased the mean number of apoptotic cells via decreasing caspase-3 and Bax as well as increasing Bcl-2 levels. In addition, MLT significantly enhanced nuclear factor-κB activation and decreased heme oxygenase-1 level. However, MLT had no effect on interleukin-6 and myelin protein production. Our data revealed that MLT improved neurological deficits and enhanced cell survival but was not able to initiate myelin production in the cuprizone model of demyelination. These findings may be important for the design of potential MLT therapy in demyelinating disorders, such as MS. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 2% |
| Germany | 1 | 2% |
| Egypt | 1 | 2% |
| Unknown | 40 | 93% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 7 | 16% |
| Student > Ph. D. Student | 6 | 14% |
| Student > Master | 5 | 12% |
| Student > Doctoral Student | 4 | 9% |
| Student > Bachelor | 3 | 7% |
| Other | 7 | 16% |
| Unknown | 11 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 9 | 21% |
| Medicine and Dentistry | 6 | 14% |
| Agricultural and Biological Sciences | 5 | 12% |
| Immunology and Microbiology | 4 | 9% |
| Biochemistry, Genetics and Molecular Biology | 3 | 7% |
| Other | 5 | 12% |
| Unknown | 11 | 26% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 28 August 2015.
All research outputs
#20,290,425
of 22,826,360 outputs
Outputs from Molecular Neurobiology
#2,792
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Outputs of similar age
#224,638
of 267,486 outputs
Outputs of similar age from Molecular Neurobiology
#75
of 106 outputs
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