| Title |
A Morpholino Oligomer Therapy Regime That Restores Mitochondrial Function and Prevents mdx Cardiomyopathy
|
|---|---|
| Published in |
JACC: Basic to Translational Science, June 2018
|
| DOI | 10.1016/j.jacbts.2018.03.007 |
| Pubmed ID | |
| Authors |
Helena M. Viola, Victoria P.A. Johnstone, Abbie M. Adams, Susan Fletcher, Livia C. Hool |
| Abstract |
Current clinical trials demonstrate Duchenne muscular dystrophy (DMD) patients receiving phosphorodiamidate morpholino oligomer (PMO) therapy exhibit improved ambulation and stable pulmonary function; however, cardiac abnormalities remain. Utilizing the same PMO chemistry as current clinical trials, we have identified a non-toxic PMO treatment regimen that restores metabolic activity and prevents DMD cardiomyopathy. We propose that a treatment regimen of this nature may have the potential to significantly improve morbidity and mortality from DMD by improving ambulation, stabilizing pulmonary function, and preventing the development of cardiomyopathy. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 7 | 27% |
| Italy | 3 | 12% |
| Spain | 2 | 8% |
| Chile | 2 | 8% |
| Australia | 1 | 4% |
| United Kingdom | 1 | 4% |
| Unknown | 10 | 38% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 15 | 58% |
| Scientists | 7 | 27% |
| Practitioners (doctors, other healthcare professionals) | 2 | 8% |
| Science communicators (journalists, bloggers, editors) | 2 | 8% |
Mendeley readers
The data shown below were compiled from readership statistics for 11 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 11 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Bachelor | 3 | 27% |
| Other | 1 | 9% |
| Professor | 1 | 9% |
| Student > Ph. D. Student | 1 | 9% |
| Researcher | 1 | 9% |
| Other | 1 | 9% |
| Unknown | 3 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 4 | 36% |
| Medicine and Dentistry | 2 | 18% |
| Chemistry | 1 | 9% |
| Neuroscience | 1 | 9% |
| Unknown | 3 | 27% |
Attention Score in Context
This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 August 2018.
All research outputs
#2,718,153
of 25,385,509 outputs
Outputs from JACC: Basic to Translational Science
#232
of 799 outputs
Outputs of similar age
#53,698
of 342,237 outputs
Outputs of similar age from JACC: Basic to Translational Science
#10
of 23 outputs
Altmetric has tracked 25,385,509 research outputs across all sources so far. Compared to these this one has done well and is in the 89th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 799 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 20.4. This one has gotten more attention than average, scoring higher than 70% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 342,237 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 84% of its contemporaries.
We're also able to compare this research output to 23 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 56% of its contemporaries.