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Mendeley readers
Attention Score in Context
| Title |
The role of activation-induced cytidine deaminase in antibody diversification, immunodeficiency, and B-cell malignancies
|
|---|---|
| Published in |
The Journal of Allergy and Clinical Immunology, October 2004
|
| DOI | 10.1016/j.jaci.2004.07.049 |
| Pubmed ID | |
| Authors |
Zhonghui Luo, Diana Ronai, Matthew D. Scharff |
| Abstract |
Before exposure to antigen, antibodies with a wide diversity of antigen-binding sites are created by V(D)J rearrangement. After exposure to antigen, further diversification is accomplished by means of somatic hypermutation of the antibody variable region genes and class-switch recombination between the heavy-chain mu constant region and the downstream gamma, epsilon, and alpha constant region. The variable region mutations are responsible for the affinity maturation of the antibody response, whereas class-switch recombination enables the antibodies to be distributed throughout the body and to carry out different effector functions. Both somatic mutation and class switching require an enzyme called activation-induced cytidine deaminase (AID) that converts deoxycytidines to deoxyuracils on single-stranded DNA. Genetic defects of AID in human subjects result in hyper-IgM syndrome type 2. The analysis of both mutant mice and immunodeficient patients has led to a better understanding of the mechanism of action and role of AID in immunity, as well as in the malignant transformation of B cells. |
Mendeley readers
The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Colombia | 1 | 2% |
| Ireland | 1 | 2% |
| Canada | 1 | 2% |
| Unknown | 55 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 13 | 22% |
| Researcher | 11 | 19% |
| Student > Master | 8 | 14% |
| Student > Bachelor | 6 | 10% |
| Other | 4 | 7% |
| Other | 7 | 12% |
| Unknown | 9 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 25 | 43% |
| Medicine and Dentistry | 8 | 14% |
| Immunology and Microbiology | 7 | 12% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Chemistry | 1 | 2% |
| Other | 1 | 2% |
| Unknown | 10 | 17% |
Attention Score in Context
This research output has an Altmetric Attention Score of 3. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 April 2021.
All research outputs
#8,534,528
of 25,371,288 outputs
Outputs from The Journal of Allergy and Clinical Immunology
#6,290
of 11,242 outputs
Outputs of similar age
#24,473
of 75,441 outputs
Outputs of similar age from The Journal of Allergy and Clinical Immunology
#31
of 59 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 43rd percentile – i.e., 43% of other outputs scored the same or lower than it.
So far Altmetric has tracked 11,242 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 17.7. This one is in the 24th percentile – i.e., 24% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 75,441 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 10th percentile – i.e., 10% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 59 others from the same source and published within six weeks on either side of this one. This one is in the 5th percentile – i.e., 5% of its contemporaries scored the same or lower than it.