| Title |
An Interferon Signature in the Peripheral Blood of Dermatomyositis Patients is Associated with Disease Activity
|
|---|---|
| Published in |
Molecular Medicine, January 2007
|
| DOI | 10.2119/2006-00085.baechler |
| Pubmed ID | |
| Authors |
Emily C. Baechler, Jason W. Bauer, Catherine A. Slattery, Ward A. Ortmann, Karl J. Espe, Jill Novitzke, Steven R. Ytterberg, Peter K. Gregersen, Timothy W. Behrens, Ann M. Reed |
| Abstract |
Recent studies have shown increased expression of interferon (IFN)-regulated genes in the peripheral blood cells of patients with systemic lupus erythematosus. A similar interferon signature has been observed in affected muscle tissue from patients with dermatomyositis (DM), but it has not yet been determined if this signature extends to the peripheral blood in DM. We performed global gene expression profiling of peripheral blood cells from adult and juvenile DM patients and healthy controls. Several interesting groups of genes were differentially expressed in DM, including genes with immune function, and others that function in muscle or are involved in mitochondrial/oxidative phosphorylation. Investigation of type I IFN-regulated transcripts revealed a striking interferon signature present in most DM patients studied. Levels of type I IFN-regulated proteins were also elevated in DM serum samples. Furthermore, both the transcript and serum protein IFN signatures were associated with disease activity. These data suggest that the IFN signature may be a useful marker for DM disease activity, and that sampling peripheral blood may be a more practical alternative to muscle biopsy for measuring this signature. |
Mendeley readers
The data shown below were compiled from readership statistics for 90 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 2 | 2% |
| Netherlands | 2 | 2% |
| Germany | 1 | 1% |
| Unknown | 85 | 94% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 20 | 22% |
| Student > Ph. D. Student | 14 | 16% |
| Student > Doctoral Student | 7 | 8% |
| Student > Bachelor | 7 | 8% |
| Student > Postgraduate | 6 | 7% |
| Other | 18 | 20% |
| Unknown | 18 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 34 | 38% |
| Agricultural and Biological Sciences | 21 | 23% |
| Biochemistry, Genetics and Molecular Biology | 6 | 7% |
| Immunology and Microbiology | 5 | 6% |
| Neuroscience | 3 | 3% |
| Other | 3 | 3% |
| Unknown | 18 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 April 2021.
All research outputs
#3,278,448
of 22,826,360 outputs
Outputs from Molecular Medicine
#117
of 1,137 outputs
Outputs of similar age
#12,717
of 156,938 outputs
Outputs of similar age from Molecular Medicine
#3
of 14 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. Compared to these this one has done well and is in the 84th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,137 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one has done well, scoring higher than 87% of its peers.
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We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.