Title |
Clinical use of an opto-nuclear probe for hybrid sentinel node biopsy guidance: first results
|
---|---|
Published in |
International Journal of Computer Assisted Radiology and Surgery, July 2018
|
DOI | 10.1007/s11548-018-1816-5 |
Pubmed ID | |
Authors |
Sergi Vidal-Sicart, Antonio Seva, Francisco Campos, Núria Sánchez, Immaculada Alonso, Jaume Pahisa, Xavier Caparrós, Andrés Perissinotti, Pilar Paredes, Fijs W. van Leeuwen |
Abstract |
Guidelines advocate the use of combined detection techniques to achieve optimal results for sentinel node (SN) biopsy. The fluorescent and radioactive (dual-) tracer ICG-99mTc-nanocolloid has been shown to facilitate SN biopsy in several indications. It was reported that an opto-nuclear probe permitted the detection of near-infrared fluorescence and gamma-rays. The aim of the current study was to evaluate this device in a large patient group and to test it in both open and laparoscopic surgery implications. Thirty-three patients scheduled for SN biopsy with the dual-tracer were retrospectively analyzed. Pre-operative lymphoscintigraphy was performed in all patients; in 18 patients (55%), a SPECT/CT scan was also performed. Radioactive and fluorescent signatures in the SNs were assessed in vivo and ex vivo using the opto-nuclear probe. One or more SNs were identified in all patients (identification rate 100%). Planar lymphoscintigraphic images revealed 95 hot spots that were considered as SNs. This number increased to 103 SNs when SPECT/CT was used. During surgery, 106 SNs were excised. In vivo, the fluorescence mode of the opto-nuclear probe was able to locate 79 SNs (74.5%). When the gamma-ray detection option of the same probe was used, this number increased to 99 SNs (93.3%). Ex vivo analysis revealed fluorescence in 93.3% of the excised nodes and radioactivity in 95.2%. This study underlines the feasibility of using the dual-tracer/opto-nuclear probe combination for SN resections. The use of the opto-nuclear technology has been extended to laparoscopic surgery. This study also underlines the fluorescence tracing can complement traditional radio-tracing approaches. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
Poland | 1 | 100% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Scientists | 1 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 15 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Other | 3 | 20% |
Researcher | 3 | 20% |
Student > Master | 2 | 13% |
Student > Ph. D. Student | 1 | 7% |
Student > Doctoral Student | 1 | 7% |
Other | 2 | 13% |
Unknown | 3 | 20% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 9 | 60% |
Biochemistry, Genetics and Molecular Biology | 1 | 7% |
Chemistry | 1 | 7% |
Materials Science | 1 | 7% |
Unknown | 3 | 20% |