| Title |
Diet-related inflammation and oesophageal cancer by histological type: a nationwide case–control study in Sweden
|
|---|---|
| Published in |
European Journal of Nutrition, July 2015
|
| DOI | 10.1007/s00394-015-0987-x |
| Pubmed ID | |
| Authors |
Yunxia Lu, Nitin Shivappa, Yulan Lin, Jesper Lagergren, James R. Hébert |
| Abstract |
This project sought to test the role of diet-related inflammation in modulating the risk of oesophageal cancer. A nationwide population-based case-control study was conducted from 1 December 1994 through 31 December 1997 in Sweden. All newly diagnosed patients with adenocarcinoma of the oesophagus or gastroesophageal junction and a randomly selected half of patients with oesophageal squamous cell carcinoma were eligible as cases. Using the Swedish Registry of the Total Population, the control group was randomly selected from the entire Swedish population and frequency-matched on age (within 10 years) and sex. The literature-derived dietary inflammatory index (DII) was developed to describe the inflammatory potential of diet. DII scores were computed based on a food frequency questionnaire. Higher DII scores indicate more pro-inflammatory diets. Odds ratios and 95 % confidence intervals (CI) were computed to assess risk associated between DII scores and oesophageal cancer using logistic regression adjusted by potential confounders. In total, 189 oesophageal adenocarcinomas, 262 gastroesophageal junctional adenocarcinomas, 167 oesophageal squamous cell carcinomas, and 820 control subjects were recruited into the study. Significant associations with DII were observed for oesophageal squamous cell carcinoma (ORQuartile4vs1 4.35, 95 % CI 2.24, 8.43), oesophageal adenocarcinoma (ORQuartile4vs1 3.59, 95 % CI 1.87, 6.89), and gastroesophageal junctional adenocarcinoma (ORQuartile4vs1 2.04, 95 % CI 1.24, 3.36). Significant trends across quartiles of DII were observed for all subtypes of oesophageal cancer. Diet-related inflammation appears to be associated with an increased risk of oesophageal cancer, regardless of histological type. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Finland | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 69 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Spain | 1 | 1% |
| Unknown | 68 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 14 | 20% |
| Student > Bachelor | 9 | 13% |
| Student > Ph. D. Student | 7 | 10% |
| Student > Doctoral Student | 6 | 9% |
| Researcher | 5 | 7% |
| Other | 4 | 6% |
| Unknown | 24 | 35% |
| Readers by discipline | Count | As % |
|---|---|---|
| Nursing and Health Professions | 17 | 25% |
| Medicine and Dentistry | 13 | 19% |
| Psychology | 2 | 3% |
| Agricultural and Biological Sciences | 2 | 3% |
| Chemistry | 2 | 3% |
| Other | 8 | 12% |
| Unknown | 25 | 36% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 31 August 2015.
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#18,425,370
of 22,826,360 outputs
Outputs from European Journal of Nutrition
#1,958
of 2,394 outputs
Outputs of similar age
#189,751
of 263,912 outputs
Outputs of similar age from European Journal of Nutrition
#48
of 64 outputs
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