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Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy

Overview of attention for article published in Scientific Reports, August 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)
  • Good Attention Score compared to outputs of the same age and source (76th percentile)

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1 blog
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2 X users

Citations

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41 Dimensions

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Title
Methamphetamine Use in HIV-infected Individuals Affects T-cell Function and Viral Outcome during Suppressive Antiretroviral Therapy
Published in
Scientific Reports, August 2015
DOI 10.1038/srep13179
Pubmed ID
Authors

Marta Massanella, Sara Gianella, Rachel Schrier, Jennifer M. Dan, Josué Pérez-Santiago, Michelli F. Oliveira, Douglas D. Richman, Susan J. Little, Constance A. Benson, Eric S. Daar, Michael P. Dube, Richard H. Haubrich, Davey M. Smith, Sheldon R. Morris

Abstract

We investigated the associations between methamphetamine (meth) use, immune function, and the dynamics of HIV and cytomegalovirus [CMV] in the blood and genital tract of HIV-infected ART-suppressed subjects. Self-reported meth use was associated with increased CD4(+) and CD8(+) T-cell proliferation (Ki67(+), p < 0.005), CD4(+) T-cell activation (CD45RA(-)CD38(+), p = 0.005) and exhaustion (PD-1(+), p = 0.0004) in blood, compared to non-meth users. Meth use was also associated with a trend towards higher blood HIV DNA levels (p = 0.09) and more frequent shedding of CMV in seminal plasma (p = 0.002). To explore possible mechanisms, we compared ex vivo spontaneous and antigen-specific proliferation in PBMC collected from subjects with and without positive meth detection in urine (Utox+ vs. Utox-). Despite higher levels of spontaneous proliferation, lymphocytes from Utox+ meth users had a significantly lower proliferative capacity after stimulation with a number of pathogens (CMV, candida, mycobacterium, toxoplasma, HIV, p < 0.04 in all cases), compared to Utox- participants. Our findings suggest that meth users have greater proliferation and exhaustion of the immune system. Meth use is also associated with a loss of control of CMV replication, which could be related to loss of immune response to pathogens. Future studies should consider meth use as a potential modulator of T-cell responses.

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X Demographics

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 2%
Switzerland 1 2%
Unknown 45 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 10 21%
Student > Master 8 17%
Researcher 4 9%
Other 3 6%
Student > Doctoral Student 2 4%
Other 7 15%
Unknown 13 28%
Readers by discipline Count As %
Immunology and Microbiology 7 15%
Agricultural and Biological Sciences 7 15%
Medicine and Dentistry 6 13%
Pharmacology, Toxicology and Pharmaceutical Science 3 6%
Nursing and Health Professions 2 4%
Other 8 17%
Unknown 14 30%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 9. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 September 2015.
All research outputs
#3,728,535
of 22,826,360 outputs
Outputs from Scientific Reports
#29,910
of 123,235 outputs
Outputs of similar age
#48,758
of 267,014 outputs
Outputs of similar age from Scientific Reports
#457
of 1,967 outputs
Altmetric has tracked 22,826,360 research outputs across all sources so far. Compared to these this one has done well and is in the 83rd percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 123,235 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 18.2. This one has done well, scoring higher than 75% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 267,014 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 1,967 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 76% of its contemporaries.